Query author contributions in Reactome
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Details on Person Distribution and free concentration of various drugs can be ...
| Class:Id | Summation:9758959 |
|---|---|
| _displayName | Distribution and free concentration of various drugs can be ... |
| _timestamp | 2022-07-26 08:26:03 |
| created | [InstanceEdit:9758957] Stephan, Ralf, 2021-11-29 |
| modified | [InstanceEdit:9759234] Stephan, Ralf, 2021-12-01 [InstanceEdit:9759237] Stephan, Ralf, 2021-12-01 [InstanceEdit:9770657] Stephan, Ralf, 2022-04-11 [InstanceEdit:9795013] Stephan, Ralf, 2022-07-26 |
| text | Distribution and free concentration of various drugs can be significantly altered as a result of their binding to serum albumin (ALB). ALB binds prednisone (PREDN) in a linear fashion. The binding is weak but, due to albumin availability, ALB bound PREDN represents a significant part of plasma protein bound PREDN at any point in time. Around 5% of total cortisol is known to be present in unbound form in plasma, and it is likely the number for PREDN is similar (Lewis et al, 2005). Prednisone and prednisolone do not displace each other at the albumin binding site (Boudinot and Jusko, 1984; Ferry and Wagner, 1987). |
| (summation) | [Reaction:9757578] ALB binds PREDN [Homo sapiens] |
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No pathways have been reviewed or authored by Distribution and free concentration of various drugs can be ... (9758959)
