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Details on Person Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex

Class:Id	Reaction:975879
_displayName	Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
_doRelease	TRUE
_timestamp	2014-08-29 13:42:12
authored	[InstanceEdit:975890] Shamovsky, V, 2010-10-06
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:975863] Shamovsky, V, 2010-10-06
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[Complex:975869] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
modified	[InstanceEdit:1181208] Shamovsky, V, 2011-01-31 [InstanceEdit:1181219] Shamovsky, V, 2011-02-01 [InstanceEdit:1216508] Shamovsky, V, 2011-02-14 [InstanceEdit:1217488] Shamovsky, V, 2011-02-16 [InstanceEdit:1221616] Shamovsky, V, 2011-02-24 [InstanceEdit:1474060] Shamovsky, V, 2011-08-04 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:5621117] Shamovsky, V, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
output	[DefinedSet:937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] [Homo sapiens] [DefinedSet:937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] [Homo sapiens] [DefinedSet:937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] [Homo sapiens] [DefinedSet:937058] hp-IRAK1/or p-IRAK2:TRAF6 [plasma membrane] [Homo sapiens] [Complex:975870] p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:975857] TRAF6 binds to hp- IRAK1 or p-IRAK2 [Homo sapiens] [Reaction:975853] Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR [Homo sapiens] [Reaction:975861] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2011-03-15
reviewed	[InstanceEdit:1186998] Gillespie, ME, 2011-02-10 [InstanceEdit:1474057] Li, L, 2011-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224938] R-HSA-975879.2
summation	[Summation:940394] Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociat...
(hasEvent)	[Pathway:975871] MyD88 cascade initiated on plasma membrane [Homo sapiens]
(precedingEvent)	[Reaction:166869] TRAF6 binds MEKK1 [Homo sapiens] [Reaction:936963] IRAK2 induces TRAF6 oligomerization [Homo sapiens] [Reaction:937044] Pellino binds hp-IRAK1:TRAF6 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788210] Update Tracker - [Reaction:975879] Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex - v43:[modifyText] [_UpdateTracker:9788528] Update Tracker - [Reaction:975879] Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex - v41:[modifyText]
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No pathways have been reviewed or authored by Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (975879)