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Details on Person IRAK4 autophosphorylation within the complex activated TLR:MyD88

Class:Id	Reaction:975865
_displayName	IRAK4 autophosphorylation within the complex activated TLR:MyD88
_doRelease	TRUE
_timestamp	2014-08-29 13:41:53
authored	[InstanceEdit:975890] Shamovsky, V, 2010-10-06
catalystActivity	[CatalystActivity:975855] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643358] protein serine/threonine kinase activity of IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] IRAK-4: a novel member of the IRAK family with the properties of an
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:975863] Shamovsky, V, 2010-10-06
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:975876] IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:446630] Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop [LiteratureReference:937035] Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
modified	[InstanceEdit:1181208] Shamovsky, V, 2011-01-31 [InstanceEdit:1216508] Shamovsky, V, 2011-02-14 [InstanceEdit:1217488] Shamovsky, V, 2011-02-16 [InstanceEdit:1221616] Shamovsky, V, 2011-02-24 [InstanceEdit:1474060] Shamovsky, V, 2011-08-04 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:5621115] Shamovsky, V, 2014-08-29 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK4 autophosphorylation within the complex activated TLR:MyD88
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:975870] p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:975873] IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor [Homo sapiens] [Reaction:975880] MyD88 oligomerization within the complex of activated TLR:MyD88 [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2011-03-15
reviewed	[InstanceEdit:1186998] Gillespie, ME, 2011-02-10 [InstanceEdit:1474057] Li, L, 2011-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224941] R-HSA-975865.3
summation	[Summation:446631] IRAK4 is activated by autophosphorylation at 3 positions wit...
(hasEvent)	[Pathway:975871] MyD88 cascade initiated on plasma membrane [Homo sapiens]
(inferredFrom)	[Reaction:977250] Autophosphorylation of IRAK4 bound to activated TLR5 or 15 [Gallus gallus]
(precedingEvent)	[Reaction:975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex [Homo sapiens]
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No pathways have been reviewed or authored by IRAK4 autophosphorylation within the complex activated TLR:MyD88 (975865)