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Details on Person IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex

Class:Id	Reaction:975852
_displayName	IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
_doRelease	TRUE
_timestamp	2014-08-29 13:41:50
authored	[InstanceEdit:975890] Shamovsky, V, 2010-10-06
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:975863] Shamovsky, V, 2010-10-06
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
input	[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens] [DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens] [DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens] [DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens] [Complex:975870] p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity [LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
modified	[InstanceEdit:1181208] Shamovsky, V, 2011-01-31 [InstanceEdit:1216508] Shamovsky, V, 2011-02-14 [InstanceEdit:1217488] Shamovsky, V, 2011-02-16 [InstanceEdit:1221616] Shamovsky, V, 2011-02-24 [InstanceEdit:1474060] Shamovsky, V, 2011-08-04 [InstanceEdit:1602499] Shamovsky, V, 2011-09-14 [InstanceEdit:5621115] Shamovsky, V, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
output	[Complex:975875] IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:975865] IRAK4 autophosphorylation within the complex activated TLR:MyD88 [Homo sapiens] [Reaction:975873] IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor [Homo sapiens]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2011-03-15
reviewed	[InstanceEdit:1186998] Gillespie, ME, 2011-02-10 [InstanceEdit:1474057] Li, L, 2011-08-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224901] R-HSA-975852.2
summation	[Summation:450116] MYD88 recruits unphosphorylated, inactive IRAK1 to the IL1 r... [Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
(hasEvent)	[Pathway:975871] MyD88 cascade initiated on plasma membrane [Homo sapiens]
(inferredFrom)	[Reaction:977237] IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex [Gallus gallus]
(precedingEvent)	[Reaction:975861] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex [Homo sapiens] [Reaction:975878] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782535] Update Tracker - [Reaction:975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex - v59:[modifyText] [_UpdateTracker:9789717] Update Tracker - [Reaction:975852] IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex - v37:[modifyText]
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No pathways have been reviewed or authored by IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (975852)