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Details on Person CASP8 cleaves N4BP1 at D424, D490

Class:Id	BlackBoxEvent:9757951
_displayName	CASP8 cleaves N4BP1 at D424, D490
_doRelease	TRUE
_timestamp	2022-05-18 13:21:37
authored	[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
catalystActivity	[CatalystActivity:9757965] cysteine-type peptidase activity of active caspase-8 [cytosol]
catalystActivityReference	[CatalystActivityReference:9757939] cysteine-type peptidase activity of active caspase-8 [cytosol] N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9757934] Shamovsky, Veronica, 2021-11-05
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
goBiologicalProcess	[GO_BiologicalProcess:160781] regulation of canonical NF-kappaB signal transduction
input	[EntityWithAccessionedSequence:9757941] N4BP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9757941] N4BP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9757963] N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
modified	[InstanceEdit:9761915] Shamovsky, Veronica, 2022-01-17 [InstanceEdit:9762356] Shamovsky, Veronica, 2022-01-20 [InstanceEdit:9773241] Shamovsky, Veronica, 2022-05-04 [InstanceEdit:9773817] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9774033] Shamovsky, Veronica, 2022-05-12 [InstanceEdit:9774121] Shamovsky, Veronica, 2022-05-17 [InstanceEdit:9774130] Matthews, Lisa, 2022-05-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CASP8 cleaves N4BP1 at D424, D490
output	[DefinedSet:9757962] N4BP1(1-424), N4BP1(1-490) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9013895] Caspase-8 processing within TLR3 complex [Homo sapiens] [Reaction:9013889] TLR3-induced ripoptosome assembly [Homo sapiens] [Reaction:2562564] Caspase-8 processing within TLR4 complex [Homo sapiens] [Reaction:2562541] TLR4-induced ripoptosome assembly [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05 [InstanceEdit:9773242] de Martin, R, 2022-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757970] R-HSA-9757951.2
summation	[Summation:9757917] NEDD4-binding protein 1 (N4BP1) limits the activation of NF-...
(hasEvent)	[Pathway:9758274] Regulation of NF-kappa B signaling [Homo sapiens]
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No pathways have been reviewed or authored by CASP8 cleaves N4BP1 at D424, D490 (9757951)