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Details on Person Pellino proteins have been implicated as mediators in mammal...
| Class:Id | Summation:975757 |
|---|---|
| _displayName | Pellino proteins have been implicated as mediators in mammal... |
| _timestamp | 2010-10-15 20:36:22 |
| created | [InstanceEdit:975755] Shamovsky, V, 2010-10-04 |
| literatureReference | [LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 [LiteratureReference:451412] The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling |
| modified | [InstanceEdit:977264] D'Eustachio, P, 2010-10-15 |
| text | Pellino proteins have been implicated as mediators in mammalian IL-1R/TLR signaling. As E3 ligases they are responsible for K63-linked polyubiquitination of IRAK1 followed by recruitment of the NEMO subunit of the IKK complex. Inspection of the chicken genome identified homologs of Pellino 1 and Pellino 2, but no orthologs for mammalian IRAK1 and NEMO, Although here we assume that chicken IRAK2 may act as mammalian IRAK2 and IRAK1 and possibly interacts with Pellino proteins, the other mechanism of chicken MyD88-dependent signaling (like lacking of IRAK1-mediated route) should be considered. |
| (summation) | [Reaction:434089] IRAK2 possibly binds to Pellino proteins [Gallus gallus] |
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