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Details on Person ST metabolites diffuse out of ER lumen

Class:Id	BlackBoxEvent:9757459
_displayName	ST metabolites diffuse out of ER lumen
_doRelease	TRUE
_timestamp	2021-11-12 15:07:58
authored	[InstanceEdit:9749700] Stephan, Ralf, 2021-08-04
compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9757460] Stephan, Ralf, 2021-11-01
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[DefinedSet:9750701] ST metabolites [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749566] Endoplasmic reticulum: a metabolic compartment
modified	[InstanceEdit:9757463] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ST metabolites diffuse out of ER lumen
output	[DefinedSet:9750699] ST metabolites [cytosol]
precedingEvent	[Reaction:9757462] Hydroxyl radicals oxidize ST to 2,3-DHBA [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [Reaction:9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [Reaction:9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [Reaction:9749977] UGT1A6 glucuronates ST [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates [Homo sapiens] [Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [Reaction:76373] N-hydroxylation of 4-aminobiphenyl [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757461] R-HSA-9757459.2
summation	[Summation:9750661] While several reactions and processes are compartmentalized ...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9750656] ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells [Homo sapiens]
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