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Details on Person ASA-,ST translocate from cytosol to ER lumen of hepatocytes

Class:Id	BlackBoxEvent:9757451
_displayName	ASA-,ST translocate from cytosol to ER lumen of hepatocytes
_doRelease	TRUE
_timestamp	2021-11-12 15:06:23
authored	[InstanceEdit:9749700] Stephan, Ralf, 2021-08-04
compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9757450] Stephan, Ralf, 2021-11-01
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[DefinedSet:9749576] ASA-, ST (hepatocyte) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749566] Endoplasmic reticulum: a metabolic compartment
modified	[InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ASA-,ST translocate from cytosol to ER lumen of hepatocytes ASA-,ST diffuse into the ER lumen
output	[DefinedSet:9749551] ASA-, ST (hepatocyte) [endoplasmic reticulum lumen]
precedingEvent	[Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens] [BlackBoxEvent:9757441] ASA- (GI) translocates from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:9757448] ST translocates from cytosol to extracellular region [Homo sapiens] [Reaction:9749609] BCHE hydrolyzes ASA- [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757452] R-HSA-9757451.2
summation	[Summation:9749794] Acetylsalicylate (ASA-) and salicylate (ST) diffuse into the...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [Reaction:9749977] UGT1A6 glucuronates ST [Homo sapiens] [Reaction:9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA [Homo sapiens] [Reaction:9749998] Hydroxyl radicals oxidize ST to 2,3-DHBA [Reaction:9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA [Homo sapiens] [BlackBoxEvent:9750672] ST translocates from cytosol to mitochondrial matrix of hepatocytes [BlackBoxEvent:9757454] ST translocates from cytosol to mitochondrial matrix of hepatocytes [Homo sapiens] [Reaction:9757462] Hydroxyl radicals oxidize ST to 2,3-DHBA [Homo sapiens]
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No pathways have been reviewed or authored by ASA-,ST translocate from cytosol to ER lumen of hepatocytes (9757451)