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Details on Person ASA- (GI) translocates from cytosol to extracellular region

Class:Id	BlackBoxEvent:9757441
_displayName	ASA- (GI) translocates from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2021-11-12 15:06:03
authored	[InstanceEdit:9749644] Stephan, Ralf, 2021-08-03
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9757442] Stephan, Ralf, 2021-11-01
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:9749785] ASA- (GI cell) [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749531] Is aspirin a substrate of MDR1/P-glycoprotein?
modified	[InstanceEdit:9757444] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758257] Stephan, Ralf, 2021-11-09 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ASA- (GI) translocates from cytosol to extracellular region Acetylsalicylate localizes to extracellular space
output	[SimpleEntity:9749598] ASA- [extracellular region]
precedingEvent	[Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9757434] Acetylsalicylic acid dissolves [Homo sapiens] [Reaction:561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [Reaction:9757434] Acetylsalicylic acid dissolves [Homo sapiens] [BlackBoxEvent:9757445] ST translocates from ER lumen to cytosol of GI cells [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [Reaction:9749647] CES2 hydrolyzes ASA- [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757443] R-HSA-9757441.2
summation	[Summation:9749569] It is not known how acetylsalicylate (ASA-) localizes out of...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens] [Reaction:9749590] ASA- acetylates ALB [Homo sapiens] [Reaction:9749609] BCHE hydrolyzes ASA- [Homo sapiens]
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No pathways have been reviewed or authored by ASA- (GI) translocates from cytosol to extracellular region (9757441)