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Details on Person SOST gene transcription is positively regulated by PAX6 and negatively regulated by PTH

Class:Id	BlackBoxEvent:9757233
_displayName	SOST gene transcription is positively regulated by PAX6 and negatively regulated by PTH
_doRelease	FALSE
_timestamp	2021-10-27 11:07:32
created	[InstanceEdit:9757234] Orlic-Milacic, Marija, 2021-10-27
input	[EntityWithAccessionedSequence:9757240] SOST gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9757215] Pax6 expressed in osteocytes inhibits canonical Wnt signaling [LiteratureReference:9757209] Isolation of osteocytes from human trabecular bone
name	SOST gene transcription is positively regulated by PAX6 and negatively regulated by PTH
output	[EntityWithAccessionedSequence:9757222] SOST mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9757237] PAX6 binds SOST gene promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9757238] Positive gene expression regulation by 'PAX6:SOST gene' [NegativeRegulation:9757231] Negative regulation by 'PTH [extracellular region]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757244] R-HSA-9757233.1
summation	[Summation:9757236] Binding of PAX6 to the SOST gene promoter stimulates SOST ge...
(hasEvent)	[Pathway:9757232] Regulation of osteocyte gene expression [Homo sapiens]
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No pathways have been reviewed or authored by SOST gene transcription is positively regulated by PAX6 and negatively regulated by PTH (9757233)