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Details on Person ABCB1,ABCC2 transport ATVs from cytosol to extracellular region

Class:Id	Reaction:9757139
_displayName	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2022-03-01 02:20:13
authored	[InstanceEdit:9757142] Jassal, Bijay, 2021-10-27
catalystActivity	[CatalystActivity:9757143] ABC-type xenobiotic transporter activity of ABCB1,ABCC2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9757142] Jassal, Bijay, 2021-10-27
edited	[InstanceEdit:9757142] Jassal, Bijay, 2021-10-27
input	[DefinedSet:9757150] ATVs [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9757141] ATP-dependent transport of statins by human and rat MRP2/Mrp2 [LiteratureReference:9757149] Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin
modified	[InstanceEdit:9757166] Jassal, Bijay, 2021-10-27 [InstanceEdit:9757252] Jassal, Bijay, 2021-10-27 [InstanceEdit:9767611] Matthews, Lisa, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCB1,ABCC2 transport ATVs from cytosol to extracellular region MRPs transport ATV and its metabolites into bile
output	[DefinedSet:9757148] ATVs [extracellular region]
precedingEvent	[BlackBoxEvent:9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL [Homo sapiens] [Reaction:9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV [Homo sapiens] [BlackBoxEvent:9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL [Homo sapiens] [Reaction:9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV [Homo sapiens] [BlackBoxEvent:9756156] UGT1A3 lactonizes ATV to ATVL [Homo sapiens] [Reaction:9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Homo sapiens] [Reaction:9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9757163] R-HSA-9757139.2
summation	[Summation:9757151] ATP-binding cassette sub-family C member 2 (ABCC2, aka MRP2)...
(hasEvent)	[Pathway:9754706] Atorvastatin ADME [Homo sapiens]
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No pathways have been reviewed or authored by ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (9757139)