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Details on Person CYP3A4 monooxygenates ATV to 4-OH-ATV

Class:Id	Reaction:9756162
_displayName	CYP3A4 monooxygenates ATV to 4-OH-ATV
_doRelease	TRUE
_timestamp	2022-03-01 02:20:19
authored	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
catalystActivity	[CatalystActivity:9756317] monooxygenase activity of CYP3A4 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
edited	[InstanceEdit:9756176] Jassal, Bijay, 2021-10-12
input	[ChemicalDrug:9705596] ATV [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9756801] Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin [LiteratureReference:9756790] Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors
modified	[InstanceEdit:9756320] Jassal, Bijay, 2021-10-13 [InstanceEdit:9756787] Jassal, Bijay, 2021-10-18 [InstanceEdit:9756895] Jassal, Bijay, 2021-10-19 [InstanceEdit:9757025] Jassal, Bijay, 2021-10-22 [InstanceEdit:9767611] Matthews, Lisa, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP3A4 monooxygenates ATV to 4-OH-ATV
output	[ChemicalDrug:9756325] 4-OH-ATV [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:9757010] SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9756193] R-HSA-9756162.2
summation	[Summation:9756792] Atorvastatin (ATV) is hydroxylated to hydroxy-metabolites, p...
(hasEvent)	[Pathway:9754706] Atorvastatin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL [Homo sapiens]
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No pathways have been reviewed or authored by CYP3A4 monooxygenates ATV to 4-OH-ATV (9756162)