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Details on Person Diagram of SARS-CoV-2-host interactions
| Class:Id | PathwayDiagram:9755933 |
|---|---|
| _displayName | Diagram of SARS-CoV-2-host interactions |
| _timestamp | 2025-11-03 16:49:41 |
| created | [InstanceEdit:9755934] Shamovsky, Veronica, 2021-10-11 |
| height | 1811 |
| modified | [InstanceEdit:9755944] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9755957] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9755967] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9755968] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9755973] Shamovsky, Veronica, 2021-10-12 [InstanceEdit:9756223] Shamovsky, Veronica, 2021-10-12 [InstanceEdit:9756473] Shamovsky, Veronica, 2021-10-14 [InstanceEdit:9756478] Shamovsky, Veronica, 2021-10-14 [InstanceEdit:9757104] Shamovsky, Veronica, 2021-10-27 [InstanceEdit:9757105] Shamovsky, Veronica, 2021-10-27 [InstanceEdit:9759655] Shamovsky, Veronica, 2021-12-10 [InstanceEdit:9765900] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9765928] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766205] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767618] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9767712] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9767746] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9767868] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9768011] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9768021] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9768138] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9768144] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9768145] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9768356] Matthews, Lisa, 2022-03-09 [InstanceEdit:9768358] Matthews, Lisa, 2022-03-10 [InstanceEdit:9768359] Matthews, Lisa, 2022-03-10 [InstanceEdit:9768362] Matthews, Lisa, 2022-03-10 [InstanceEdit:9768363] Matthews, Lisa, 2022-03-10 [InstanceEdit:9768364] Matthews, Lisa, 2022-03-10 [InstanceEdit:9773801] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9774030] Shamovsky, Veronica, 2022-05-12 [InstanceEdit:9774031] Shamovsky, Veronica, 2022-05-12 [InstanceEdit:9774077] Matthews, Lisa, 2022-05-13 [InstanceEdit:9774105] Matthews, Lisa, 2022-05-16 [InstanceEdit:9796647] Shamovsky, Veronica, 2022-08-10 [InstanceEdit:9815389] Shamovsky, Veronica, 2022-08-17 [InstanceEdit:9927590] Matthews, Lisa, 2024-11-08 [InstanceEdit:9928226] Matthews, Lisa, 2024-11-12 [InstanceEdit:9928227] Matthews, Lisa, 2024-11-12 [InstanceEdit:9928228] Matthews, Lisa, 2024-11-12 [InstanceEdit:9957237] Shamovsky, Veronica, 2025-06-17 [InstanceEdit:9960376] Shamovsky, Veronica, 2025-07-10 [InstanceEdit:9970960] Shamovsky, Veronica, 2025-11-03 |
| representedPathway | [Pathway:9705683] SARS-CoV-2-host interactions [Homo sapiens] |
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id="317" reactomeId="29356" position="926 1156" bounds="905 1141 43 31" textPosition="909 1145" /> <org.gk.render.RenderableProtein id="318" reactomeId="167923" position="887 1196" bounds="867 1185 40 23" textPosition="867 1185"> <Properties> <displayName>TAB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="319" reactomeId="9729751" position="1022 1137" bounds="979 1126 87 23" textPosition="979 1126"> <Properties> <displayName>TAB1(1-444)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="320" reactomeId="9729698" position="1099 1168" bounds="1056 1157 87 23" textPosition="1056 1157"> <Properties> <displayName>TAB1(1-132)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="321" reactomeId="9729724" position="1182 1202" bounds="1131 1191 103 23" textPosition="1131 1191"> <Properties> <displayName>TAB1(133-504)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="322" reactomeId="9729691" position="1073 1230" bounds="1022 1219 103 23" textPosition="1022 1219"> <Properties> <displayName>TAB1(445-504)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="371" reactomeId="9708916" position="1059 1426" bounds="1051 1415 17 23" textPosition="1051 1415" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="372" reactomeId="157689" position="1101 1473" bounds="1053 1455 96 37" textPosition="1053 1456" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Nuclear Pore Complex (NPC)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="373" reactomeId="9708891" position="950 1468" bounds="928 1457 45 23" textPosition="928 1458" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>6:NPC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="374" reactomeId="350" position="915 1579" bounds="718 1463 394 233" textPosition="961 1490" bgColor="250 240 240" lineColor="255 153 102" insets="727 1473 378 215"> <Properties> <displayName>nucleolus</displayName> </Properties> <Components> <Component id="373" /> <Component id="372" /> <Component id="1421" /> <Component id="733" /> <Component id="734" /> <Component id="735" /> <Component id="732" /> <Component id="736" /> <Component id="737" /> <Component id="738" /> <Component id="3034" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="376" reactomeId="9709655" position="1234 949" bounds="1187 938 95 23" textPosition="1187 939" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>9b homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="377" reactomeId="1252129" position="1118 1004" bounds="1087 993 62 23" textPosition="1087 993"> <Properties> <displayName>TOMM70</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="378" reactomeId="9709659" position="1000 1003" bounds="959 992 82 23" textPosition="959 993" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TOMM70:9b</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="380" reactomeId="9754828" position="1221 1010" bounds="1171 999 101 23" textPosition="1171 1000" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>9b:IKK complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="381" reactomeId="168113" position="1350 946" bounds="1291 935 118 23" textPosition="1291 936" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHUK:IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="391" reactomeId="9694302" position="1602 483" bounds="1586 472 33 23" textPosition="1586 473" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>RTC</displayName> </Properties> <OldBounds> <Bounds id="391" bounds="1617 330 49 25" /> </OldBounds> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="396" reactomeId="983114" position="165 837" bounds="107 819 116 37" textPosition="107 820" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Antigen peptide bound class I MHC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="397" reactomeId="9755345" position="275 853" bounds="232 842 87 23" textPosition="232 843" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>8 homodimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="398" reactomeId="9755340" position="223 946" bounds="165 928 116 37" textPosition="165 929" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>8:antigen peptide bound class I MHC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="400" reactomeId="5683379" position="95 985" bounds="40 974 110 23" textPosition="40 975" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Beclin-1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="401" reactomeId="9755322" position="163 1089" bounds="96 1071 134 37" textPosition="96 1072" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>8:class I MHC:BECN1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="409" reactomeId="447176" position="324 265" bounds="299 254 50 23" textPosition="299 254"> <Properties> <displayName>IL17RA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="410" reactomeId="9755409" position="324 210" bounds="281 199 87 23" textPosition="281 200" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="411" reactomeId="9755355" position="436 265" bounds="405 254 62 23" textPosition="405 255" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>8:IL17RA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="435" reactomeId="9689606" position="663 1250" bounds="643 1239 41 23" textPosition="643 1239"> <Properties> <displayName>MPP5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="436" reactomeId="9705682" position="667 1417" bounds="610 1406 115 23" textPosition="610 1407" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>MMP5:E pentamer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="458" reactomeId="532659" position="459 1472" bounds="441 1461 36 23" textPosition="441 1461"> <Properties> <displayName>TJP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="459" reactomeId="9754656" position="535 1419" bounds="482 1408 107 23" textPosition="482 1409" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TJP1:E pentamer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="503" reactomeId="9730510" position="265 1199" bounds="240 1188 50 23" textPosition="240 1188"> <Properties> <displayName>UVRAG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="504" reactomeId="9694598" position="168 1188" bounds="122 1170 92 37" textPosition="122 1171" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="505" reactomeId="9730524" position="189 1370" bounds="130 1352 118 37" textPosition="130 1353" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>UVRAG:O-glycosyl 3a tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="510" reactomeId="2197808" position="999 540" bounds="952 529 95 23" textPosition="952 530" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HOPS Complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="511" reactomeId="9754528" position="872 564" bounds="826 546 92 37" textPosition="826 547" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="512" reactomeId="9754533" position="964 674" bounds="935 663 59 23" textPosition="935 664" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>HOPS:3a</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="513" reactomeId="1660539" position="905 623" bounds="788 565 234 117" textPosition="801 629" bgColor="250 240 240" lineColor="255 153 102" insets="798 575 215 96"> <Properties> <displayName>endolysosome lumen</displayName> </Properties> <Components> <Component id="511" /> <Component id="509" /> <Component id="512" /> <Component id="525" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="518" reactomeId="9694750" position="692 716" bounds="680 705 24 23" textPosition="680 705" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableProtein id="525" reactomeId="9755945" position="790 600" bounds="778 589 24 23" textPosition="778 589" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>7a</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="533" reactomeId="9754777" position="829 836" bounds="809 825 41 23" textPosition="809 825"> <Properties> <displayName>TUFM</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="534" reactomeId="9754785" position="814 917" bounds="787 906 55 23" textPosition="787 907" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TUFM:M</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="542" reactomeId="5205651" position="801 1107" bounds="766 1096 71 23" textPosition="766 1096"> <Properties> <displayName>MAP1LC3B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="546" reactomeId="9755946" position="728 982" bounds="668 971 121 23" textPosition="668 972" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>MAP1LC3B:TUFM:M</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="557" reactomeId="61459" position="1735 1734" bounds="1711 1723 48 23" textPosition="1711 1723"> <Properties> <displayName>PDPK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="558" reactomeId="9755780" position="1689 1732" bounds="1680 1721 19 23" textPosition="1680 1721" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableComplex id="559" reactomeId="9755778" position="1845 1732" bounds="1808 1721 75 23" textPosition="1808 1722" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:M:PDPK1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="560" reactomeId="9694407" position="959 1252" bounds="921 1241 77 23" textPosition="921 1242" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>3CLp dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="580" reactomeId="1834940" position="529 1073" bounds="507 1062 44 23" textPosition="507 1062"> <Properties> <displayName>STING</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="581" reactomeId="9730518" position="671 1070" bounds="607 1059 128 23" textPosition="607 1060" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>STING:3CLpro dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="584" reactomeId="9730525" position="388 1197" bounds="323 1179 131 37" textPosition="323 1180" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>STING:O-glycosyl 3a tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="597" reactomeId="9729832" position="1470 1487" bounds="1422 1469 96 37" textPosition="1422 1470" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>40S ribosomal complex:nsp1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="598" reactomeId="9694741" position="1302 1489" bounds="1283 1478 38 23" textPosition="1283 1478" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>nsp1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="599" reactomeId="72392" position="1339 1448" bounds="1291 1430 96 37" textPosition="1291 1431" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>40S ribosomal complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="611" reactomeId="29804" position="92 1680" bounds="75 1665 35 31" textPosition="79 1669" /> <org.gk.render.RenderableChemical id="612" reactomeId="74126" position="91 1787" bounds="74 1772 35 31" textPosition="78 1776"> <Properties> <displayName>K+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="613" reactomeId="9694306" position="190 1739" bounds="144 1721 92 37" textPosition="144 1722" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>O-glycosyl 3a tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="660" reactomeId="9694770" position="1687 487" bounds="1668 476 38 23" textPosition="1668 476" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>nsp6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="661" reactomeId="9705026" position="1877 527" bounds="1818 516 119 23" textPosition="1818 517" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TBK1:pp1ab-nsp6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="677" reactomeId="9694642" position="1677 562" bounds="1631 551 92 23" textPosition="1631 551" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>pp1ab-nsp13</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="678" reactomeId="9705087" position="1834 567" bounds="1771 556 127 23" textPosition="1771 557" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TBK1:pp1ab-nsp13</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="682" reactomeId="9694702" position="1368 818" bounds="1340 807 56 23" textPosition="1340 808" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="683" reactomeId="9755729" position="1249 904" bounds="1222 893 54 23" textPosition="1222 894" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:MAVS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="699" reactomeId="9717677" position="1485 797" bounds="1453 786 64 23" textPosition="1453 787" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>DDX58:N</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="701" reactomeId="918186" position="1600 756" bounds="1573 745 54 23" textPosition="1573 745"> <Properties> <displayName>TRIM25</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="702" reactomeId="9729447" position="1703 821" bounds="1670 810 67 23" textPosition="1670 811" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>TRIM25:N</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="704" reactomeId="446878" position="1507 977" bounds="1460 966 94 23" textPosition="1460 967" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TAK1 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="705" reactomeId="9755745" position="1510 1096" bounds="1459 1085 103 23" textPosition="1459 1086" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:TAK1complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="709" reactomeId="9755930" position="1405 1058" bounds="1340 1047 131 23" textPosition="1340 1048" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:CHUK:IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="711" reactomeId="9729448" position="1718 950" bounds="1674 939 89 23" textPosition="1674 939"> <Properties> <displayName>STAT1,STAT2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="712" reactomeId="9729443" position="1657 1068" bounds="1606 1057 102 23" textPosition="1606 1058" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>STAT1,STAT2:N</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="714" reactomeId="9729488" position="1640 914" bounds="1595 903 91 23" textPosition="1595 903"> <Properties> <displayName>G3BP1,G3BP2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="715" reactomeId="9729513" position="1583 1023" bounds="1531 1012 104 23" textPosition="1531 1013" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>G3BP1,G3BP2:N</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="729" reactomeId="9705293" position="534 1197" bounds="526 1186 17 23" textPosition="526 1186" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.RenderableProtein id="730" reactomeId="205976" position="535 1154" bounds="511 1143 49 23" textPosition="511 1143"> <Properties> <displayName>KPNA2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="731" reactomeId="9705285" position="656 1201" bounds="626 1190 61 23" textPosition="626 1191" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>KPNA2:6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="733" reactomeId="9730487" position="790 1577" bounds="744 1566 92 23" textPosition="744 1566" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>pp1ab-nsp16</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableRNA id="734" reactomeId="71911" position="785 1633" bounds="736 1614 99 39" textPosition="752 1622"> <Properties> <displayName>U1 snRNA</displayName> </Properties> </org.gk.render.RenderableRNA> 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lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>nsp8</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="741" reactomeId="445238" position="1695 1405" bounds="1666 1394 58 23" textPosition="1666 1394"> <Properties> <displayName>7SL RNA</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="742" reactomeId="9729808" position="1754 1501" bounds="1709 1490 91 23" textPosition="1709 1491" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>7SL RNA:nsp8</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="744" reactomeId="9694286" position="1598 1405" bounds="1552 1394 92 23" textPosition="1552 1395" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>nsp9 tetramer</displayName> </Properties> 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position="1115 580" bounds="1058 569 115 23" textPosition="1058 570" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TBK1/IKBKE:SIKE1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="869" reactomeId="918196" position="1315 644" bounds="1252 605 126 79" textPosition="1252 606" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="870" reactomeId="916828" position="1292 579" bounds="1272 568 41 23" textPosition="1272 568"> <Properties> <displayName>SIKE1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="910" reactomeId="168928" position="1486 720" bounds="1420 684 132 73" textPosition="1420 684"> <Properties> <displayName>DDX58/IFIH1-mediated induction of interferon-alpha/beta</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="951" reactomeId="9755962" position="1418 495" bounds="1354 470 129 51" textPosition="1354 471" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SARS-CoV-2 dsRNA intermediates:DDX58</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1046" reactomeId="166058" position="828 289" bounds="762 253 132 73" textPosition="761 260"> <Properties> <displayName>MyD88:MAL(TIRAP) cascade initiated on plasma membrane</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntity id="1059" reactomeId="450152" position="1771 741" bounds="1735 730 73 23" textPosition="1735 730"> <Properties> <displayName>K63polyUb</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntitySet id="1060" reactomeId="936435" position="1878 764" bounds="1824 746 109 37" textPosition="1824 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1154"> <Properties> <displayName>Interferon alpha/beta signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="1179" reactomeId="447091" position="199 202" bounds="140 184 119 37" textPosition="140 184"> <Properties> <displayName>IL17A dimer,IL17F dimer,IL17A:IL17F</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1180" reactomeId="447216" position="248 277" bounds="223 266 50 23" textPosition="223 266"> <Properties> <displayName>IL17RC</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1181" reactomeId="448403" position="68 303" bounds="10 278 116 51" textPosition="10 279" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1185" reactomeId="448424" position="111 396" bounds="59 374 104 45" textPosition="59 374"> <Properties> <displayName>Interleukin-17 signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1221" reactomeId="2317313" position="2090 1505" bounds="2036 1487 108 37" textPosition="2036 1488" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S-AKT:PDPK1:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1222" reactomeId="113592" position="1996 1525" bounds="1976 1510 40 31" textPosition="1980 1514" /> <org.gk.render.RenderableChemical id="1223" reactomeId="29370" position="1960 1603" bounds="1940 1588 41 31" textPosition="1944 1592" /> <org.gk.render.RenderableComplex id="1224" reactomeId="377179" position="2113 1611" bounds="2075 1600 77 23" textPosition="2075 1601" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PDPK1:PIP3</displayName> </Properties> </org.gk.render.RenderableComplex> 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<org.gk.render.ProcessNode id="1382" reactomeId="445989" position="1335 1269" bounds="1268 1240 134 59" textPosition="1269 1240"> <Properties> <displayName>TAK1-dependent IKK and NF-kappa-B activation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="1420" reactomeId="450256" position="815 1405" bounds="749 1387 132 37" textPosition="749 1387" /> <org.gk.render.RenderableEntitySet id="1421" reactomeId="450349" position="813 1529" bounds="747 1511 132 37" textPosition="747 1511"> <Properties> <displayName>phosphorylated IRF3 and/or IRF7 dimer</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1527" reactomeId="191791" position="1200 1595" bounds="1149 1577 103 37" textPosition="1149 1578" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SMN:SM protein complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1528" reactomeId="191853" position="1206 1640" bounds="1144 1622 125 37" textPosition="1144 1623" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>m7G capped Spliceosomal snRNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1529" reactomeId="191813" position="1392 1612" bounds="1326 1580 132 65" textPosition="1326 1581" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1539" reactomeId="194441" position="1220 1698" bounds="1155 1676 130 45" textPosition="1155 1676"> <Properties> <displayName>Metabolism of non-coding RNA</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1550" reactomeId="9709836" position="941 1051" bounds="886 1040 111 23" textPosition="886 1041" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HSP90:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1551" reactomeId="9709860" position="864 1010" bounds="815 999 98 23" textPosition="815 1000" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MAVS:TOMM70</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1552" reactomeId="9709857" position="938 831" bounds="883 813 111 37" textPosition="883 814" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MAVS:TOMM70:HSP90:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1591" reactomeId="1799339" position="1872 1345" bounds="1806 1309 132 73" textPosition="1806 1309"> <Properties> <displayName>SRP-dependent cotranslational protein targeting to membrane</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="1998" reactomeId="9694702" position="1708 1678" bounds="1680 1667 56 23" textPosition="1680 1668" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1999" reactomeId="389744" position="1595 1327" bounds="1546 1316 99 23" textPosition="1546 1316"> <Properties> <displayName>PTPN6,PTPN11</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="2012" reactomeId="71185" position="1505 853" bounds="1467 838 77 31" textPosition="1471 842"> <Properties> <displayName>ferroheme</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="2179" reactomeId="9694408" position="312 1414" bounds="262 1396 101 37" textPosition="262 1397" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableChemical id="2181" reactomeId="167012" position="401 1369" bounds="376 1354 50 31" textPosition="380 1358" /> <org.gk.render.RenderableChemical id="2184" reactomeId="76183" position="1776 1070" bounds="1746 1055 61 31" textPosition="1750 1059"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2185" reactomeId="76194" position="1898 1082" bounds="1867 1067 62 31" textPosition="1871 1071"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="2187" reactomeId="9756493" position="1827 1103" bounds="1801 1092 53 23" textPosition="1801 1092"> <Properties> <displayName>CREBBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2198" reactomeId="9694500" position="478 175" bounds="411 143 134 65" textPosition="410 144" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2199" reactomeId="5686241" position="405 64" bounds="361 53 88 23" textPosition="361 54" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SFTPD 12mer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2200" reactomeId="9756571" position="602 91" bounds="539 52 126 79" textPosition="539 53" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>SFTPD:S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2227" reactomeId="561189" position="1291 790" bounds="1268 779 47 23" textPosition="1268 779"> <Properties> <displayName>NLRP3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2228" reactomeId="9757077" position="1332 911" bounds="1302 900 60 23" textPosition="1302 901" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:NLRP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2229" reactomeId="9758478" position="1062 1049" bounds="1028 1038 69 23" textPosition="1028 1038" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>p-S53-9b</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.2318840579710145" relativeY="0.0" label="P" trackId="0" reactomeId="9758487" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2234" reactomeId="9697429" position="983 105" bounds="955 94 56 23" textPosition="955 95" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true" /> <org.gk.render.RenderableComplex id="2235" reactomeId="166710" position="835 40" bounds="778 15 114 51" textPosition="778 16" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2236" reactomeId="9758533" position="1135 80" bounds="1072 55 127 51" textPosition="1072 56" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2328" reactomeId="113592" position="1759 681" bounds="1739 666 40 31" textPosition="1743 670" /> <org.gk.render.RenderableComplex id="2329" reactomeId="9705133" position="1659 636" bounds="1592 583 134 107" textPosition="1592 584" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2330" reactomeId="9710999" position="1902 638" bounds="1839 592 126 93" textPosition="1839 593" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE)</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="2331" reactomeId="29370" position="1809 682" bounds="1789 667 41 31" textPosition="1793 671" /> <org.gk.render.RenderableProtein id="2385" reactomeId="168917" position="1366 772" bounds="1341 761 51 23" textPosition="1341 761"> <Properties> <displayName>DDX58</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2537" reactomeId="9759645" position="1940 291" bounds="1920 280 40 23" textPosition="1920 280"> <Properties> <displayName>CNBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="2538" reactomeId="9759710" position="2017 334" bounds="1954 316 127 37" textPosition="1954 316" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>SARS-CoV-2 G-rich RNA:RTC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="2539" reactomeId="9759705" position="2022 420" bounds="1962 402 121 37" textPosition="1962 403" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CNBP:SARS-CoV-2 G-rich RNA:RTC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2544" reactomeId="9694458" position="1961 474" bounds="1900 456 122 37" textPosition="1900 457" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>SARS-CoV-2 gRNA:RTC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2545" reactomeId="9760421" position="2065 477" bounds="2042 466 46 23" textPosition="2042 466"> <Properties> <displayName>LARP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2546" reactomeId="9760493" position="2002 564" bounds="1939 546 127 37" textPosition="1939 547" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>LARP1:SARS-CoV-2 gRNA:RTC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2554" reactomeId="190583" position="388 1557" bounds="331 1532 115 51" textPosition="331 1533" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Connexin 43 connexon in Golgi transport vesicle</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="2555" reactomeId="191615" position="552 1538" bounds="517 1527 71 23" textPosition="517 1528" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Cx43:TJP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="2560" reactomeId="622433" position="508 1595" bounds="401 1530 215 131" textPosition="407 1612" bgColor="250 240 240" lineColor="255 153 102" insets="411 1540 197 110"> <Properties> <displayName>Golgi-associated vesicle lumen</displayName> </Properties> <Components> <Component id="2554" /> <Component id="2555" /> <Component id="2679" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="2561" reactomeId="9756485" position="1994 1044" bounds="1932 1019 125 51" textPosition="1932 1020" bgColor="204 255 255" lineColor="255 0 0" isForDisease="true" hideComponents="true"> <Properties> <displayName>SUMO1-K62,ADPr-,p-11S,2T,met-2R,Ac-K375-N dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2562" reactomeId="9759641" position="1867 403" bounds="1813 392 108 23" textPosition="1813 392"> <Properties> <displayName>MeR25,27-CNBP</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16203703703703703" relativeY="0.0" label="Me" trackId="0" reactomeId="9759672" /> <org.gk.render.RenderableFeature relativeX="0.33796296296296297" relativeY="0.0" label="Me" trackId="0" reactomeId="9759659" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2563" reactomeId="9767620" position="750 777" bounds="741 766 19 23" textPosition="741 766" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.ProcessNode id="2572" reactomeId="446728" position="429 1735" bounds="384 1713 91 45" textPosition="384 1713"> <Properties> <displayName>Cell junction organization</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="2646" reactomeId="168643" position="191 1545" bounds="125 1495 132 101" textPosition="123 1502"> <Properties> <displayName>Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="2647" reactomeId="9767684" position="1641 850" bounds="1614 839 54 23" textPosition="1614 840" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>N:heme</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="2674" reactomeId="166658" position="1213 199" bounds="1157 176 113 46" textPosition="1167 177"> <Properties> <displayName>Complement cascade</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="2677" reactomeId="157858" position="322 1643" bounds="270 1614 104 59" textPosition="270 1614"> <Properties> <displayName>Gap junction trafficking and regulation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="3035" reactomeId="113592" position="1277 1043" bounds="1257 1028 40 31" textPosition="1261 1032" /> <org.gk.render.RenderableComplex id="3036" reactomeId="202513" position="1330 1173" bounds="1271 1155 118 37" textPosition="1271 1156" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHUK:p-S177,S181-IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="3037" reactomeId="29370" position="1257 1133" bounds="1237 1118 41 31" textPosition="1241 1122" /> <org.gk.render.RenderableChemical id="3042" reactomeId="74112" position="726 76" bounds="701 61 50 31" textPosition="705 65" /> <org.gk.render.RenderableComplex id="3043" reactomeId="9957085" position="1036 197" bounds="947 157 178 80" textPosition="951 159" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="3" reactomeId="9755765" points="980 370, 980 396, 981 429" position="980 396" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="1033 370" /> <Input id="5" points="980 326" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> <Inhibitors> <Inhibitor id="7" points="953 395" /> </Inhibitors> <Properties> <displayName>C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="9754830" points="1168 419, 1167 494, 1073 494" position="1167 494" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="1128 393" /> <Input id="12" points="1200 316" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="9755368" points="552 238, 577 238, 600 252" position="577 238" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2198" points="516 211" /> <Input id="16" points="532 254" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Properties> <displayName>TLR2:TLR1 binds SARS-CoV-2 E pentamer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="9754745" points="1517 414, 1518 515, 1518 542" position="1518 515" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="26" points="1517 321" /> <Input id="27" points="1584 377" /> </Inputs> <Outputs> <Output id="28" points="1541 539" /> <Output id="29" points="1519 565" /> </Outputs> <Inhibitors> <Inhibitor id="391" points="1583 489" /> </Inhibitors> <Properties> <displayName>IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="9755258" points="1386 418, 1387 439, 1403 467" position="1387 439" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="32" stoichiometry="2" points="1352 374" /> <Input id="33" points="1420 379" /> <Input id="34" stoichiometry="2" points="1349 414" /> </Inputs> <Outputs> <Output id="951" /> </Outputs> <Inhibitors> <Inhibitor id="391" points="1583 479" /> </Inhibitors> <Properties> <displayName>DDX58 binds SARS-CoV-2 dsRNA intermediates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="9755244" points="340 629, 390 629, 416 629" position="390 629" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="140" points="274 597" /> <Input id="91" points="271 640" /> </Inputs> <Outputs> <Output id="92" points="498 568" /> <Output id="165" points="464 649" /> </Outputs> <Catalysts> <Catalyst id="93" points="403 701" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="94" reactomeId="9729725" points="346 609, 371 609, 396 610" position="371 609" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="96" points="293 559" /> <Input id="91" points="271 636" /> </Inputs> <Outputs> <Output id="92" points="489 563" /> <Output id="97" points="501 615" /> </Outputs> <Catalysts> <Catalyst id="93" points="401 701" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 nsp3 deISGylates ISGylated IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="185" reactomeId="9729730" points="585 608, 615 608, 640 609" position="615 608" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="186" points="573 592" /> <Input id="97" points="541 613" /> </Inputs> <Outputs> <Output id="187" points="662 620" /> <Output id="188" points="662 597" /> </Outputs> <Catalysts> <Catalyst id="93" points="458 713, 616 699" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 nsp3 cleaves IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="227" reactomeId="9754827" points="800 728, 819 729, 846 730" position="819 729" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="228" points="761 728" /> <Input id="236" points="795 718" /> </Inputs> <Outputs> <Output id="229" /> </Outputs> <Properties> <displayName>SARS-CoV-2 M binds TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="238" reactomeId="9716160" points="1141 797, 1101 798, 1077 818" position="1101 798" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2563" points="763 776, 1183 775" /> <Input id="239" points="1225 820" /> </Inputs> <Outputs> <Output id="240" /> </Outputs> <Properties> <displayName>SARS-CoV-2 M protein binds MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="302" reactomeId="9754616" points="401 1388, 403 1416, 405 1448" position="403 1416" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="2181" /> </Inputs> <Outputs> <Output id="304" /> </Outputs> <Catalysts> <Catalyst id="2179" points="366 1397, 380 1392" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 E pentamer transports Ca2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="308" reactomeId="9729741" points="939 1324, 963 1324, 994 1324" position="963 1324" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="309" stoichiometry="2" points="931 1344" /> <Input id="310" points="931 1314" /> </Inputs> <Outputs> <Output id="311" points="1074 1339" /> <Output id="312" points="1066 1377" /> <Output id="313" points="1055 1316" /> <Output id="314" points="1065 1288" /> </Outputs> <Catalysts> <Catalyst id="560" points="959 1267" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 3CLpro dimer cleaves NLRP12</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="316" reactomeId="9729704" points="938 1196, 960 1197, 995 1198" position="960 1197" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="317" stoichiometry="2" points="930 1175" /> <Input id="318" points="910 1196" /> </Inputs> <Outputs> <Output id="319" points="1016 1152" /> <Output id="320" points="1059 1183" /> <Output id="321" points="1128 1200" /> <Output id="322" points="1044 1216" /> </Outputs> <Catalysts> <Catalyst id="560" points="959 1238" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 3CLpro dimer cleaves TAB1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="370" reactomeId="9708889" points="1030 1444, 1006 1445, 976 1458" position="1006 1445" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="371" points="1048 1431" /> <Input id="372" points="1055 1452" /> </Inputs> <Outputs> <Output id="373" /> </Outputs> <Properties> <displayName>SARS-CoV-2 6 binds NUP98:RAE1 within NPC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="375" reactomeId="9709663" points="1104 977, 1066 977, 1029 989" position="1066 977" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="376" points="1184 959" /> <Input id="377" points="1112 990" /> </Inputs> <Outputs> <Output id="378" /> </Outputs> <Inhibitors> <Inhibitor id="2229" points="1062 1035" /> </Inhibitors> <Properties> <displayName>SARS-CoV-2 9b binds TOMM70</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="379" reactomeId="9754839" points="1295 982, 1294 1006, 1275 1007" position="1294 1006" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="376" points="1255 964" /> <Input id="381" points="1332 961" /> </Inputs> <Outputs> <Output id="380" /> </Outputs> <Properties> <displayName>SARS-CoV-2 9b binds IKBKG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="395" reactomeId="9755328" points="222 877, 222 897, 222 925" position="222 897" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="396" points="191 859" /> <Input id="397" points="249 868" /> </Inputs> <Outputs> <Output id="398" /> </Outputs> <Properties> <displayName>SARS-CoV-2 8 binds class I MHC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="399" reactomeId="9755359" points="163 1009, 163 1033, 163 1068" position="163 1033" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="400" points="127 1000" /> <Input id="398" points="205 968" /> </Inputs> <Outputs> <Output id="401" /> </Outputs> <Properties> <displayName>SARS-CoV-2 8:class I MHC binds BECN1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="408" reactomeId="9755413" points="356 232, 379 233, 415 251" position="379 233" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="409" points="335 251" /> <Input id="410" points="340 225" /> </Inputs> <Outputs> <Output id="411" /> </Outputs> <Properties> <displayName>SARS-CoV-2 8 binds IL17RA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="434" reactomeId="9705681" points="669 1354, 670 1374, 667 1403" position="670 1374" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="305" points="644 1316" /> <Input id="435" points="680 1265, 704 1277" /> </Inputs> <Outputs> <Output id="436" /> </Outputs> <Properties> <displayName>MPP5 binds SARS-CoV-2 E pentamer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="457" reactomeId="9754644" points="532 1356, 533 1380, 534 1405" position="533 1380" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="305" points="602 1316" /> <Input id="458" points="462 1458, 505 1327" /> </Inputs> <Outputs> <Output id="459" /> </Outputs> <Properties> <displayName>SARS-CoV-2 E pentamer binds TJP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="502" reactomeId="9730505" points="258 1261, 257 1281, 203 1349" position="257 1281" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="503" points="263 1214" /> <Input id="504" points="190 1210" /> </Inputs> <Outputs> <Output id="505" /> </Outputs> <Properties> <displayName>SARS-CoV-2 3a binds to UVRAG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="509" reactomeId="9754537" points="958 598, 958 620, 962 660" position="958 620" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="510" points="990 555" /> <Input id="511" points="921 582" /> </Inputs> <Outputs> <Output id="512" /> </Outputs> <Properties> <displayName>SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="517" reactomeId="9754554" points="692 702, 693 677, 775 609" position="693 677" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="518" /> </Inputs> <Outputs> <Output id="525" /> </Outputs> <Properties> <displayName>SARS-COV 7a translocates to the late endosome membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="532" reactomeId="9754763" points="784 863, 786 886, 803 903" position="786 886" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="533" points="809 851" /> <Input id="2563" points="754 792" /> </Inputs> <Outputs> <Output id="534" /> </Outputs> <Properties> <displayName>SARS-CoV-2 M protein binds TUFM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="541" reactomeId="9754775" points="777 1036, 762 1035, 735 997" position="762 1035" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="534" points="810 932" /> <Input id="542" points="797 1093" /> </Inputs> <Outputs> <Output id="546" /> </Outputs> <Properties> <displayName>SARS-CoV-2 M protein binds MAP1LC3B</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="556" reactomeId="9755777" points="1776 1706, 1799 1706, 1824 1718" position="1799 1706" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="558" points="1693 1718, 1699 1706" /> <Input id="557" points="1751 1720" /> <Input id="1998" points="1739 1689" /> </Inputs> <Outputs> <Output id="559" /> </Outputs> <Properties> <displayName>SARS-CoV-2 M, N bind to PDPK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="579" reactomeId="9730501" points="582 1102, 625 1101, 653 1085" position="625 1101" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="580" points="550 1088" /> <Input id="560" points="922 1238, 522 1115" /> </Inputs> <Outputs> <Output id="581" /> </Outputs> <Properties> <displayName>SARS-CoV-2 3CLpro dimer binds to STING</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="582" reactomeId="9730528" points="258 1151, 307 1149, 356 1176" position="307 1149" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="580" points="504 1077, 218 1137" /> <Input id="504" points="213 1167" /> </Inputs> <Outputs> <Output id="584" /> </Outputs> <Properties> <displayName>SARS-CoV-2 3a binds to STING</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="596" reactomeId="9729849" points="1367 1485, 1391 1486, 1419 1486" position="1391 1486" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="598" points="1327 1487" /> <Input id="599" points="1353 1470" /> </Inputs> <Outputs> <Output id="597" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp1 binds to 40S ribosomal complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="610" reactomeId="9730521" points="92 1699, 92 1734, 91 1769" position="92 1734" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="611" /> </Inputs> <Outputs> <Output id="612" /> </Outputs> <Catalysts> <Catalyst id="613" points="141 1746, 115 1751" /> </Catalysts> <Properties> <displayName>SARS-CoV-2 3a induces potassium efflux</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="659" reactomeId="9705010" points="1745 523, 1777 523, 1815 524" position="1777 523" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="200" points="1712 527" /> <Input id="660" points="1712 498" /> </Inputs> <Outputs> <Output id="661" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp6 binds TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="676" reactomeId="9705082" points="1730 537, 1778 536, 1813 553" position="1778 536" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="200" points="1712 533" /> <Input id="677" points="1701 548" /> </Inputs> <Outputs> <Output id="678" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp13 binds TBK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="681" reactomeId="9755747" points="1292 851, 1293 875, 1266 890" position="1293 875" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="682" points="1341 833" /> <Input id="239" points="1272 837" /> </Inputs> <Outputs> <Output id="683" /> </Outputs> <Inhibitors> <Inhibitor id="2561" points="1954 1016, 1760 892, 1747 887" /> </Inhibitors> <Properties> <displayName>SARS-CoV-2 N binds MAVS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="698" reactomeId="9717658" points="1399 797, 1423 796, 1450 796" position="1423 796" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="682" points="1384 804" /> <Input id="2385" points="1381 787" /> </Inputs> <Outputs> <Output id="699" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds DDX58</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="700" reactomeId="9729437" points="1575 817, 1599 817, 1667 819" position="1599 817" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="682" points="1399 817" /> <Input id="701" points="1595 771" /> </Inputs> <Outputs> <Output id="702" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds to TRIM25</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="703" reactomeId="9755757" points="1459 1009, 1459 1030, 1501 1082" position="1459 1030" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="704" points="1489 992" /> <Input id="682" points="1373 833" /> </Inputs> <Outputs> <Output id="705" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds TAK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="708" reactomeId="9755734" points="1401 984, 1402 1005, 1404 1044" position="1402 1005" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="381" points="1365 961" /> <Input id="682" points="1372 833, 1431 970" /> </Inputs> <Outputs> <Output id="709" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds IKBKB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="710" reactomeId="9729454" points="1655 991, 1656 1016, 1656 1054" position="1656 1016" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="711" points="1700 968" /> <Input id="682" points="1387 833" /> </Inputs> <Outputs> <Output id="712" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N protein binds STAT1, STAT2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="713" reactomeId="9729481" points="1584 961, 1583 981, 1583 1009" position="1583 981" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="714" points="1626 932" /> <Input id="682" points="1385 833" /> </Inputs> <Outputs> <Output id="715" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds to G3BP1,G3BP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="728" reactomeId="9705299" points="567 1183, 588 1184, 623 1193" position="588 1184" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="729" points="546 1193" /> <Input id="730" points="547 1169" /> </Inputs> <Outputs> <Output id="731" /> </Outputs> <Properties> <displayName>SARS-CoV-2 6 binds KPNA2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="732" reactomeId="9730483" points="879 1603, 903 1603, 924 1603" position="903 1603" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="734" points="838 1617" /> <Input id="733" points="829 1592" /> </Inputs> <Outputs> <Output id="735" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp16 binds to U1 snRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="736" reactomeId="9730488" points="884 1625, 906 1625, 983 1648" position="906 1625" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="733" points="812 1592" /> <Input id="737" points="834 1653" /> </Inputs> <Outputs> <Output id="738" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp16 binds to U2 snRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="739" reactomeId="9729841" points="1750 1439, 1750 1461, 1752 1487" position="1750 1461" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="740" points="1763 1423" /> <Input id="741" points="1713 1423" /> </Inputs> <Outputs> <Output id="742" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp8 binds to 7SL RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="743" reactomeId="9729835" points="1644 1442, 1644 1461, 1644 1478" position="1644 1461" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="741" points="1679 1423" /> <Input id="744" points="1612 1420" /> </Inputs> <Outputs> <Output id="745" /> </Outputs> <Properties> <displayName>SARS-CoV-2 nsp9 binds to 7SL RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="750" reactomeId="9729500" points="1730 1017, 1729 1047, 1729 1118" position="1729 1047" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="751" points="1787 1001" /> <Input id="682" points="1388 833" /> </Inputs> <Outputs> <Output id="752" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds to 14-3-3 proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="753" reactomeId="9754518" points="219 1247, 218 1274, 185 1299" position="218 1274" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="754" points="193 1248" /> <Input id="504" points="183 1210" /> </Inputs> <Outputs> <Output id="755" /> </Outputs> <Properties> <displayName>SARS-CoV-2 3a tetramer binds to CAV1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="837" interactionType="Activate" points="922 450, 898 450" position="910 450" lineWidth="2.0"> <Inputs> <Input id="6" /> </Inputs> <Outputs> <Output id="835" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="839" interactionType="Activate" points="951 480, 898 466" position="924 473" lineWidth="2.0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="835" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="843" reactomeId="420661" points="685 1701, 650 1701, 626 1709" position="650 1701" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="844" points="731 1724" /> <Input id="845" points="690 1723" /> <Input id="846" points="802 1731" /> </Inputs> <Outputs> <Output id="847" /> </Outputs> <Inhibitors> <Inhibitor id="436" points="655 1432, 640 1443" /> </Inhibitors> <Properties> <displayName>Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="866" reactomeId="918225" points="1202 577, 1221 578, 1242 579" position="1221 578" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="867" points="1169 600" /> <Input id="868" points="1176 578" /> </Inputs> <Outputs> <Output id="869" points="1270 602" /> <Output id="870" points="1269 579" /> </Outputs> <Inhibitors> <Inhibitor id="229" points="906 731, 1219 732" /> </Inhibitors> <Properties> <displayName>TBK1/IKK epsilon complex interacts with MAVS bound TRAF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="912" interactionType="Activate" points="1515 608, 1495 681" position="1505 644" lineWidth="2.0"> <Inputs> <Input id="29" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="956" interactionType="Activate" points="1425 524, 1474 681" position="1449 602" lineWidth="2.0"> <Inputs> <Input id="951" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1051" interactionType="Activate" points="732 286, 759 286" position="745 286" lineWidth="2.0"> <Inputs> <Input id="17" /> </Inputs> <Outputs> <Output id="1046" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1058" reactomeId="918224" points="1817 815, 1818 842, 1935 916" position="1818 842" lineWidth="1.0"> <Inputs> <Input id="1059" stoichiometry="2" points="1778 756" /> <Input id="1060" stoichiometry="2" points="1855 789" /> <Input id="1061" points="1764 802" /> </Inputs> <Outputs> <Output id="1062" /> </Outputs> <Catalysts> <Catalyst id="1060" points="1871 789, 1860 813" /> </Catalysts> <Inhibitors> <Inhibitor id="702" points="1740 827, 1800 841" /> </Inhibitors> <Properties> <displayName>DDX58 is K63 polyubiquitinated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1071" interactionType="Activate" points="2012 916, 2076 842, 2068 717, 1555 719" position="2072 779" lineWidth="2.0"> <Inputs> <Input id="1062" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1075" reactomeId="983426" points="184 785, 213 784, 266 784" position="213 784" lineWidth="1.0"> <Inputs> <Input id="396" points="171 816" /> <Input id="1076" points="166 785" /> </Inputs> <Outputs> <Output id="1077" /> </Outputs> <Inhibitors> <Inhibitor id="401" points="233 1071, 337 1044, 338 838, 212 804" /> </Inhibitors> <Properties> <displayName>Capturing cargo and formation of prebudding complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1090" interactionType="Activate" points="394 784, 419 784" position="406 784" lineWidth="2.0"> <Inputs> <Input id="1077" /> </Inputs> <Outputs> <Output id="1088" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1143" reactomeId="909726" points="1533 1275, 1574 1276, 1610 1276" position="1574 1276" lineWidth="1.0"> <Inputs> <Input id="1144" points="1508 1279" /> <Input id="1145" points="1518 1300" /> <Input id="1146" points="1522 1262" /> </Inputs> <Outputs> <Output id="1147" points="1620 1260" /> <Output id="1148" points="1658 1276" /> </Outputs> <Catalysts> <Catalyst id="1146" points="1548 1262" /> </Catalysts> <Inhibitors> <Inhibitor id="1999" points="1590 1310" /> <Inhibitor id="712" points="1636 1083, 1573 1116" /> </Inhibitors> <Properties> <displayName>Phosphorylation of STAT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1157" interactionType="Activate" points="1698 1242, 1679 1216" position="1688 1229" lineWidth="2.0"> <Inputs> <Input id="1148" /> </Inputs> <Outputs> <Output id="1155" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1178" reactomeId="447246" points="196 257, 143 257, 109 275" position="143 257" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1179" points="197 227" /> <Input id="1180" points="220 267" /> <Input id="409" points="296 263" /> </Inputs> <Outputs> <Output id="1181" /> </Outputs> <Activators> <Activator id="411" points="435 280, 435 299, 143 298" /> </Activators> <Properties> <displayName>IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1187" interactionType="Activate" points="80 332, 100 371" position="90 351" lineWidth="2.0"> <Inputs> <Input id="1181" /> </Inputs> <Outputs> <Output id="1185" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1220" reactomeId="198270" points="2034 1545, 2034 1573, 2036 1593" position="2034 1573" lineWidth="1.0" reactionType="Transition"> <Inputs> <Input id="1221" points="2064 1527" /> <Input id="1222" points="2019 1535" /> </Inputs> <Outputs> <Output id="1223" points="1984 1600" /> <Output id="1224" points="2072 1602" /> <Output id="1225" points="2028 1618" /> </Outputs> <Catalysts> <Catalyst id="1221" points="2074 1527" /> </Catalysts> <Inhibitors> <Inhibitor id="559" points="1844 1718, 1843 1573" /> </Inhibitors> <Properties> <displayName>PDPK1 phosphorylates AKT at T308</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1241" interactionType="Activate" points="2023 1653, 2018 1670" position="2020 1661" lineWidth="2.0"> <Inputs> <Input id="1225" /> </Inputs> <Outputs> <Output id="1239" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1254" interactionType="Inhibit" points="1484 783, 1484 760" position="1484 771" lineWidth="2.0"> <Inputs> <Input id="699" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1256" interactionType="Inhibit" points="1657 1083, 1659 1151" position="1658 1117" lineWidth="2.0"> <Inputs> <Input id="712" /> </Inputs> <Outputs> <Output id="1155" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1360" reactomeId="168184" points="1324 1043, 1327 1094, 1326 1114" position="1327 1094" lineWidth="1.0"> <Inputs> <Input id="3035" stoichiometry="2" points="1300 1043" /> <Input id="381" points="1346 961" /> </Inputs> <Outputs> <Output id="3036" points="1328 1152" /> <Output id="3037" stoichiometry="2" points="1281 1127" /> </Outputs> <Catalysts> <Catalyst id="1364" points="1249 1092" /> </Catalysts> <Activators> <Activator id="705" points="1456 1086, 1448 1084" /> <Activator id="709" points="1380 1073" /> </Activators> <Properties> <displayName>Activated TAK1 mediates phosphorylation of the IKK Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1391" interactionType="Inhibit" points="1001 1252, 1242 1253, 1265 1257" position="1242 1253" lineWidth="2.0"> <Inputs> <Input id="560" /> </Inputs> <Outputs> <Output id="1382" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1526" reactomeId="191786" points="1276 1612, 1296 1612, 1323 1612" position="1296 1612" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1528" points="1252 1619" /> <Input id="1527" points="1255 1606" /> </Inputs> <Outputs> <Output id="1529" /> </Outputs> <Inhibitors> <Inhibitor id="735" points="984 1590, 993 1565, 1295 1565" /> <Inhibitor id="738" points="1024 1648, 1060 1572, 1280 1572" /> </Inhibitors> <Properties> <displayName>snRNP complex assembly</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1541" interactionType="Activate" points="1323 1642, 1261 1673" position="1292 1657" lineWidth="2.0"> <Inputs> <Input id="1529" /> </Inputs> <Outputs> <Output id="1539" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1549" reactomeId="9709852" points="938 973, 937 926, 937 853" position="937 926" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1550" points="940 1037" /> <Input id="1551" points="887 996" /> </Inputs> <Outputs> <Output id="1552" /> </Outputs> <Inhibitors> <Inhibitor id="378" points="993 989, 958 925" /> </Inhibitors> <Properties> <displayName>MAVS:TOMM70 recruits HSP90:TBK1:IRF3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1573" interactionType="Activate" points="937 810, 936 760, 1417 724" position="936 760" lineWidth="2.0"> <Inputs> <Input id="1552" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="2011" reactomeId="9756470" points="1530 827, 1579 828, 1611 840" position="1579 828" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2012" points="1519 835" /> <Input id="682" points="1399 819" /> </Inputs> <Outputs> <Output id="2647" /> </Outputs> <Properties> <displayName>N binds to heme</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2183" reactomeId="9756494" points="1801 1039, 1825 1040, 1849 1040" position="1825 1040" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="682" points="1390 833" /> <Input id="2184" points="1788 1052" /> </Inputs> <Outputs> <Output id="2185" points="1879 1064" /> <Output id="2561" points="1929 1042" /> </Outputs> <Catalysts> <Catalyst id="2187" points="1826 1089" /> </Catalysts> <Properties> <displayName>CREBBP acetylates SARS-CoV-2 N at K375</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2197" reactomeId="9756574" points="478 90, 511 90, 536 90" position="511 90" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2198" points="478 140" /> <Input id="2199" points="437 79" /> </Inputs> <Outputs> <Output id="2200" /> </Outputs> <Properties> <displayName>SARS-CoV-2 S binds SFTPD 12mer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2226" reactomeId="9757097" points="1329 845, 1330 864, 1331 897" position="1330 864" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2227" points="1298 805" /> <Input id="682" points="1351 833" /> </Inputs> <Outputs> <Output id="2228" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds NLRP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2233" reactomeId="9758529" points="1021 80, 1042 80, 1069 80" position="1042 80" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="2234" points="1000 91" /> <Input id="2235" points="895 52" /> </Inputs> <Outputs> <Output id="2236" /> </Outputs> <Properties> <displayName>SARS-CoV-2 N binds MASP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2327" reactomeId="9705320" points="1757 636, 1779 636, 1807 636" position="1779 636" lineWidth="1.0"> <Inputs> <Input id="2328" points="1758 663" /> <Input id="2329" points="1729 629" /> </Inputs> <Outputs> <Output id="2330" points="1836 636" /> <Output id="2331" points="1808 664" /> </Outputs> <Catalysts> <Catalyst id="2329" points="1729 636" /> </Catalysts> <Inhibitors> <Inhibitor id="678" points="1824 582" /> </Inhibitors> <Properties> <displayName>TBK1, IKBKE are autophosphorylated at Ser172</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2536" reactomeId="9759709" points="1965 370, 1964 387, 1989 399" position="1964 387" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2537" points="1939 306, 1937 352" /> <Input id="2538" points="1990 359" /> </Inputs> <Outputs> <Output id="2539" /> </Outputs> <Inhibitors> <Inhibitor id="2562" points="1924 394" /> </Inhibitors> <Properties> <displayName>CNBP binds SARS-CoV-2 G-rich RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2543" reactomeId="9760510" points="2031 501, 2031 519, 2033 534, 2021 543" position="2031 519" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2544" points="2008 496" /> <Input id="2545" points="2048 492" /> </Inputs> <Outputs> <Output id="2546" /> </Outputs> <Properties> <displayName>LARP1 binds SARS-CoV-2 RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2553" reactomeId="190541" points="461 1513, 487 1513, 522 1524" position="487 1513" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="458" points="459 1487" /> <Input id="2554" points="430 1529" /> </Inputs> <Outputs> <Output id="2555" /> </Outputs> <Inhibitors> <Inhibitor id="459" points="527 1434, 486 1496" /> </Inhibitors> <Properties> <displayName>Association of Cx43 with TJP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="2649" interactionType="Activate" points="378 1475, 260 1520" position="319 1497" lineWidth="2.0"> <Inputs> <Input id="304" /> </Inputs> <Outputs> <Output id="2646" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2653" interactionType="Activate" points="524 1733, 495 1736, 478 1735" position="495 1736" lineWidth="2.0"> <Inputs> <Input id="847" /> </Inputs> <Outputs> <Output id="2572" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2657" interactionType="Activate" points="1901 688, 1901 702, 1555 717" position="1901 702" lineWidth="2.0"> <Inputs> <Input id="2330" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2659" interactionType="Activate" points="1381 671, 1417 689" position="1399 680" lineWidth="2.0"> <Inputs> <Input id="869" /> </Inputs> <Outputs> <Output id="910" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="2679" interactionType="Activate" points="527 1553, 377 1620" position="452 1586" lineWidth="2.0"> <Inputs> <Input id="2555" /> </Inputs> <Outputs> <Output id="2677" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3034" reactomeId="9768142" points="814 1430, 814 1467, 813 1505" position="814 1467" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1420" /> </Inputs> <Outputs> <Output id="1421" /> </Outputs> <Inhibitors> <Inhibitor id="373" points="943 1454, 930 1431" /> <Inhibitor id="731" points="671 1216, 940 1411" /> </Inhibitors> <Properties> <displayName>Dimerized phospho-IRF3, IRF7 is transported to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3039" interactionType="Activate" points="1330 1195, 1333 1237" position="1331 1216" lineWidth="2.0"> <Inputs> <Input id="3036" /> </Inputs> <Outputs> <Output id="1382" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="3041" reactomeId="9957161" points="868 94, 908 94, 986 154" position="908 94" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="2235" points="850 69" /> <Input id="3042" points="754 79" /> <Input id="2198" points="548 161" /> </Inputs> <Outputs> <Output id="3043" /> </Outputs> <Properties> <displayName>MBL2 binds SARS-CoV-2 S</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="3049" interactionType="Activate" points="1128 197, 1154 197" position="1141 197" lineWidth="2.0"> <Inputs> <Input id="3043" /> </Inputs> <Outputs> <Output id="2674" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3095" interactionType="Activate" points="1711 1388, 1785 1344, 1803 1344" position="1785 1344" lineWidth="2.0"> <Inputs> <Input id="741" /> </Inputs> <Outputs> <Output id="1591" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3122" interactionType="Activate" points="1337 1427, 1336 1407" position="1336 1417" lineWidth="2.0"> <Inputs> <Input id="599" /> </Inputs> <Outputs> <Output id="1250" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="3124" interactionType="Activate" points="103 1662, 153 1599" position="128 1630" lineWidth="2.0"> <Inputs> <Input id="611" /> </Inputs> <Outputs> <Output id="2646" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of SARS-CoV-2-host interactions (9755933)
