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Details on Person SARS-CoV-2 8:class I MHC binds BECN1

Class:Id	Reaction:9755359
_displayName	SARS-CoV-2 8:class I MHC binds BECN1
_doRelease	TRUE
_timestamp	2024-05-16 16:48:08
authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:5263265] lumenal side of endoplasmic reticulum membrane
created	[InstanceEdit:9755396] Shamovsky, Veronica, 2021-10-08
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[Complex:9755340] 8:antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] [Homo sapiens] [Complex:5683379] Beclin-1 complex [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9755378] The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι
modified	[InstanceEdit:9756124] Shamovsky, Veronica, 2021-10-12 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766342] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767649] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9910706] D'Eustachio, Peter, 2024-05-16
name	SARS-CoV-2 8:class I MHC binds BECN1
output	[Complex:9755322] 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9755328] SARS-CoV-2 8 binds class I MHC [Homo sapiens] [Reaction:983138] Transport of MHC heterotrimer to ER exit site [Homo sapiens] [Reaction:9755354] 8 forms a homodimer [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9755433] R-HSA-9755359.3
summation	[Summation:9756125] SARS-CoV-2 ORF8 (8), which has no orthologous protein in SAR...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-2 8:class I MHC binds BECN1 (9755359)