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Details on Person SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1

Class:Id	Reaction:9755244
_displayName	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
_doRelease	TRUE
_timestamp	2022-03-01 03:17:36
authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
catalystActivity	[CatalystActivity:9729742] ISG15-specific peptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755238] Shamovsky, Veronica, 2021-10-07
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[Complex:9755926] ISGylated IFIH1 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9755246] ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
modified	[InstanceEdit:9755927] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766343] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767652] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
output	[EntityWithAccessionedSequence:936552] ISG15 [cytosol] [Homo sapiens] [Complex:918203] IFIH1:TKFC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9694389] nsp3 is glycosylated [Homo sapiens] [Reaction:9694601] nsp3-4 cleaves itself [Homo sapiens] [Reaction:9694625] nsp3 cleaves nsp1-4 [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9755259] R-HSA-9755244.2
summation	[Summation:9755235] Interferon-induced helicase C domain-containing protein 1 (I...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
(precedingEvent)	[Reaction:9754745] IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (9755244)