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Details on Person ITPA dimer dephosphorylates RBV-TP to RBV-MP

Class:Id	Reaction:9755030
_displayName	ITPA dimer dephosphorylates RBV-TP to RBV-MP
_doRelease	TRUE
_timestamp	2022-06-25 07:24:23
authored	[InstanceEdit:9755068] Stephan, Ralf, 2021-09-20
catalystActivity	[CatalystActivity:9755010] nucleoside triphosphate diphosphatase activity of ITPA dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755067] Stephan, Ralf, 2021-10-05
edited	[InstanceEdit:9767894] Stephan, Ralf, 2022-03-02
input	[SimpleEntity:9754951] RBV-TP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9755039] Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus [LiteratureReference:9755003] Induction of inosine triphosphatase activity during ribavirin treatment for chronic hepatitis C [LiteratureReference:9755059] ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
modified	[InstanceEdit:9767893] Stephan, Ralf, 2022-03-02 [InstanceEdit:9773825] Stephan, Ralf, 2022-05-10 [InstanceEdit:9773915] Matthews, Lisa, 2022-05-11 [InstanceEdit:9793977] Stephan, Ralf, 2022-06-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ITPA dimer dephosphorylates RBV-TP to RBV-MP ITPA dimer hydrolyzes RBV-TP
output	[SimpleEntity:9755028] RBV-MP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:9755013] NME1,2 hexamers phosphorylate RBV-DP [Homo sapiens] [BlackBoxEvent:9754978] Unknown kinase phosphorylates RBV-MP [Homo sapiens]
releaseDate	2022-09-14
reviewed	[InstanceEdit:9793976] Thorn, Caroline, 2022-06-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9755114] R-HSA-9755030.2
summation	[Summation:9754908] Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitr...
(hasEvent)	[Pathway:9755088] Ribavirin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9755078] NT5C2 tetramer dephosphorylates RBV-MP [Homo sapiens] [NegativePrecedingEvent:9761239] Futile Cycle: ITPA dimer dephosphorylates RBV-TP to RBV-MP
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No pathways have been reviewed or authored by ITPA dimer dephosphorylates RBV-TP to RBV-MP (9755030)