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Details on Person SLC29A1 transports RBV from extracellular region to cytosol

Class:Id	Reaction:9755015
_displayName	SLC29A1 transports RBV from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2022-06-25 07:25:26
authored	[InstanceEdit:9755068] Stephan, Ralf, 2021-09-20
catalystActivity	[CatalystActivity:9754995] nucleoside transmembrane transporter activity of SLC29A1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9755067] Stephan, Ralf, 2021-10-05
edited	[InstanceEdit:9767894] Stephan, Ralf, 2022-03-02
input	[ChemicalDrug:9755082] RBV [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9754949] Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters [LiteratureReference:9754973] Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake [LiteratureReference:9754889] Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2 [LiteratureReference:9755008] Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes [LiteratureReference:9754971] Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes [LiteratureReference:9755065] Drug transporter pharmacogenetics in nucleoside-based therapies [LiteratureReference:9755032] Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters
modified	[InstanceEdit:9767893] Stephan, Ralf, 2022-03-02 [InstanceEdit:9773825] Stephan, Ralf, 2022-05-10 [InstanceEdit:9773915] Matthews, Lisa, 2022-05-11 [InstanceEdit:9793975] Stephan, Ralf, 2022-06-24 [InstanceEdit:9793977] Stephan, Ralf, 2022-06-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC29A1 transports RBV from extracellular region to cytosol SLC29A1 imports RBV
output	[ChemicalDrug:9680963] RBV [cytosol]
releaseDate	2022-09-14
reviewed	[InstanceEdit:9793976] Thorn, Caroline, 2022-06-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9755095] R-HSA-9755015.2
summation	[Summation:9754969] The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) i...
(hasEvent)	[Pathway:9755088] Ribavirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix [Homo sapiens] [Reaction:9755044] PNP trimer transforms RBV to T-CONH2 [Homo sapiens]
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