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Details on Person NME1,2 hexamers phosphorylate RBV-DP

Class:Id	Reaction:9755013
_displayName	NME1,2 hexamers phosphorylate RBV-DP
_doRelease	TRUE
_timestamp	2022-06-25 07:24:30
authored	[InstanceEdit:9755068] Stephan, Ralf, 2021-09-20
catalystActivity	[CatalystActivity:482613] nucleoside diphosphate kinase activity of NME1,2 hexamers [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755067] Stephan, Ralf, 2021-10-05
edited	[InstanceEdit:9767894] Stephan, Ralf, 2022-03-02
input	[SimpleEntity:9754985] RBV-DP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9754963] Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets [LiteratureReference:9755072] Cellular phosphorylation of anti-HIV nucleosides. Role of nucleoside diphosphate kinase
modified	[InstanceEdit:9767893] Stephan, Ralf, 2022-03-02 [InstanceEdit:9773825] Stephan, Ralf, 2022-05-10 [InstanceEdit:9773915] Matthews, Lisa, 2022-05-11 [InstanceEdit:9793977] Stephan, Ralf, 2022-06-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NME1,2 hexamers phosphorylate RBV-DP
output	[SimpleEntity:9754951] RBV-TP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:9754978] Unknown kinase phosphorylates RBV-MP [Homo sapiens] [Reaction:9754974] ADK phosphorylates RBV [Homo sapiens] [Reaction:9754916] NT5C2 tetramer phosphorylates RBV [Homo sapiens]
releaseDate	2022-09-14
reviewed	[InstanceEdit:9793976] Thorn, Caroline, 2022-06-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9755110] R-HSA-9755013.2
summation	[Summation:9754962] Both nucleoside diphosphate kinases A and B (NME1, NME2) hex...
(hasEvent)	[Pathway:9755088] Ribavirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9754929] SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix [Homo sapiens] [Reaction:9755030] ITPA dimer dephosphorylates RBV-TP to RBV-MP [Homo sapiens]
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No pathways have been reviewed or authored by NME1,2 hexamers phosphorylate RBV-DP (9755013)