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Details on Person UniProt:Q9JHG7 Pik3cg
| Class:Id | ReferenceGeneProduct:97550 |
|---|---|
| _chainChangeLog | chain:1-1102 added on Sat February 7 2015 |
| _displayName | UniProt:Q9JHG7 Pik3cg |
| _timestamp | 2025-02-21 20:13:03 |
| chain | chain:1-1102 |
| checksum | 7675848792D76734 |
| comment | FUNCTION Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:10669418, PubMed:11054537). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (PubMed:10669416). Links G-protein coupled receptor activation to PIP3 production (PubMed:10669416). Involved in immune, inflammatory and allergic responses (PubMed:10669416, PubMed:10669418, PubMed:16127437, PubMed:31554793). Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge (PubMed:10669416). Controls motility of dendritic cells (PubMed:15318168). Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation (PubMed:16116162, PubMed:19297623). Participates in T-lymphocyte migration (PubMed:19297623). Regulates T-lymphocyte proliferation, activation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis (PubMed:17673465). Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism (PubMed:17673465). May have also a lipid kinase activity-dependent function in platelet aggregation (PubMed:17673465). Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility (PubMed:12297047). Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels (PubMed:12297047, PubMed:15294162, PubMed:21474070). Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation (PubMed:21474070). Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis (By similarity). May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (PubMed:22728827).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)ACTIVITY REGULATION Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunit PIK3R5 leading to the translocation from the cytosol to the plasma membrane and to kinase activation; the respective activation involving PIK3R6 requires HRAS for membrane recruitment. Wortmannin sensitive in nM range. Inhibited by AS252424.PATHWAY Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.SUBUNIT Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. Interacts with GRK2 through the PIK helical domain (By similarity). Interaction with GRK2 is required for targeting to agonist-occupied receptor. Interacts with PDE3B; regulates PDE3B activity and thereby cAMP levels in cells (PubMed:15294162). Interacts with TPM2 (By similarity). Interacts with EPHA8; regulates integrin-mediated cell adhesion to substrate. Interacts with HRAS; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6.INTERACTION Phosphorylated at Thr-1024 by PKA. Phosphorylation inhibits lipid kinase activity.PTM Autophosphorylation at Ser-1101 has no effect on the phosphatidylinositol-4,5-bisphosphate 3-kinase activity.DISRUPTION PHENOTYPE PIK3CG-null mice are viable and fertile, and display immunological abnormalities when the immune system is stressed. There is reduced T(reg) cells amount, reduced levels of IgG, enhanced IL12 production in macrophages, and increased T-cell infiltration in the gut (PubMed:31554793). Leukocyte migration in response to chemotactic agents and towards the site of inflammation, as well as neutrophil oxidative burst in response to chemotactic agents are decreased. Mutant mice show reduced thymocyte survival, defective T lymphocyte activation, and are protected from leukocyte infiltration of synovia in a model of rheumatoid arthritis. Dendritic cell showed reduced response to chemokines and migration to draining lymph nodes under inflammatory conditions. Platelets have defects in thrombus formation. PIK3CG-null mice show increased cardiac contractility, and display myocardial damage after transverse aortic constriction.SIMILARITY Belongs to the PI3/PI4-kinase family. |
| description | recommendedName: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform shortName: PI3-kinase subunit gamma shortName: PI3K-gamma shortName: PI3Kgamma shortName: PtdIns-3-kinase subunit gamma ecNumber evidence="10"2.7.1.137 ecNumber evidence="2"2.7.1.153 ecNumber evidence="2"2.7.1.154 alternativeName: Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma shortName: PtdIns-3-kinase subunit p110-gamma shortName: p110gamma alternativeName: Phosphoinositide-3-kinase catalytic gamma polypeptide alternativeName: fullName evidence="2"Serine/threonine protein kinase PIK3CG ecNumber evidence="2"2.7.11.1 alternativeName: p120-PI3K |
| geneName | Pik3cg Pi3kg1 |
| identifier | Q9JHG7 |
| isSequenceChanged | FALSE |
| keyword | Angiogenesis ATP-binding Cell membrane Chemotaxis Cytoplasm Direct protein sequencing Endocytosis Immunity Inflammatory response Kinase Lipid metabolism Membrane Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Pik3cg |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PK3CG_MOUSE Q80V09 |
| sequenceLength | 1102 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9027212] Pik3cg [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9JHG7 Pik3cg (97550)
