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Details on Person The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) i...
| Class:Id | Summation:9754969 |
|---|---|
| _displayName | The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) i... |
| _timestamp | 2022-06-24 15:38:59 |
| created | [InstanceEdit:9755067] Stephan, Ralf, 2021-10-05 |
| modified | [InstanceEdit:9761905] Stephan, Ralf, 2022-01-16 [InstanceEdit:9793975] Stephan, Ralf, 2022-06-24 |
| text | The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) is directly involved in the transport of ribavirin (RBV) into cells, although a molecular mechanism has not been defined. It is possible that the observed dependency of RBV uptake on the presence of SLC29A1 is mediated by its binding to SLC28C2,3 (Yamamoto et al, 2010; Fukuchi et al, 2010). The role of equilibrative nucleoside transporter 2 (ENT2, SLC29A2) seems to be minor, at least in placental cells (Owen et al, 2005; Govindajaran et al, 2008; Nishimura et al, 2019). As both concentrative and equilibrative transporters are ubiquitously expressed, RBV may be absorbed extensively (Jarvis et al, 1998; Errasti-Murugarren and Pastor-Anglada, 2010). |
| (summation) | [Reaction:9755015] SLC29A1 transports RBV from extracellular region to cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by The equilibrative nucleoside transporter 1 (ENT1, SLC29A1) i... (9754969)
