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Details on Person Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitr...
| Class:Id | Summation:9754908 |
|---|---|
| _displayName | Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitr... |
| _timestamp | 2021-10-05 09:34:17 |
| created | [InstanceEdit:9755067] Stephan, Ralf, 2021-10-05 |
| text | Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitro by recombinant ITP triphosphatase (ITPAse, ITPA) to a similar extent as its naturally occurring substrate ITP. Reduced ITPase activity in one third of humans causes increased intracellular levels of RBV-TP, leading to increased treatment efficacy (Nystrom et al, 2018; Tanaka et al, 2018). Polymorphisms in the gene encoding ITPase (ITPA) have been associated with protection against ribavirin-induced anemia (Fellay et al, 2010). |
| (summation) | [Reaction:9755030] ITPA dimer dephosphorylates RBV-TP to RBV-MP [Homo sapiens] |
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No pathways have been reviewed or authored by Ribavirin triphosphate (RBV-TP) was dephosphorylated in vitr... (9754908)
