Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates

Class:Id	Reaction:9754745
_displayName	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates
_doRelease	TRUE
_timestamp	2022-03-01 03:07:00
authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
compartment	[Compartment:70101] cytosol [Compartment:9684675] double membrane vesicle viral factory outer membrane
created	[InstanceEdit:9754747] Shamovsky, Veronica, 2021-10-02
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[Complex:918203] IFIH1:TKFC [cytosol] [Homo sapiens] [DefinedSet:9754749] SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9755230] MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells [LiteratureReference:9755226] SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells
modified	[InstanceEdit:9754826] Shamovsky, Veronica, 2021-10-05 [InstanceEdit:9755232] Shamovsky, Veronica, 2021-10-07 [InstanceEdit:9755964] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9764239] Stephan, Ralf, 2022-02-10 [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766341] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767619] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates dsRNA binds to MDA5
output	[EntityWithAccessionedSequence:918185] TKFC [cytosol] [Homo sapiens] [Complex:9754743] SARS-CoV-2 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane] [Homo sapiens]
precedingEvent	[Reaction:9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 [Homo sapiens] [BlackBoxEvent:9694389] nsp3 is glycosylated [Homo sapiens]
regulatedBy	[NegativeRegulation:9755965] Negative regulation by 'RTC [double membrane vesicle viral factory outer membrane]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9754755] R-HSA-9754745.2
summation	[Summation:9754742] Coronaviruses (CoVs) are positive-sense RNA viruses that rep...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
(inferredFrom)	[Reaction:9693590] SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates (9754745)