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Details on Person SARS-CoV-2-encoded ORF7a (7a) was shown to localize to the l...

Class:IdSummation:9754557
_displayNameSARS-CoV-2-encoded ORF7a (7a) was shown to localize to the l...
_timestamp2022-02-17 05:13:09
created[InstanceEdit:9754572] Shamovsky, Veronica, 2021-09-29
literatureReference[LiteratureReference:9754570] Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities
[LiteratureReference:9754567] Manipulation of autophagy by SARS-CoV-2 proteins
modified[InstanceEdit:9756268] Shamovsky, Veronica, 2021-10-12
[InstanceEdit:9765906] Shamovsky, Veronica, 2022-02-17
textSARS-CoV-2-encoded ORF7a (7a) was shown to localize to the late endosomal compartment, co-localizing with the marker Rab9 upon co-expression of tagged proteins in HeLa cells (Hayn M et al. 2021). Further, the maturation of autophagosomes was assessed by mCherry-GFP-LC3B reporter system and pH-dependent lysotracker upon expression of viral 7a in human embryonic kidney 293T (HEK293T) cells (Hayn M et al. 2021). The effect of 7a on lysosomal-autophagosomal fusion was assessed by colocalization studies in HeLa cells using the lysosomal marker LAMP1 and the autophagosome marker LC3B (Hayn M et al. 2021). The results suggest that SARS-CoV-2 7a blocks autophagic flux in human cells by reducing acidity of lysosome (Hayn M et al. 2021; Koepke L et al. 2021).
(summation)[BlackBoxEvent:9754554] SARS-COV 7a translocates to the late endosome membrane [Homo sapiens]
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