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Details on Person LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene

Class:Id	Reaction:9754191
_displayName	LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene
_doRelease	TRUE
_timestamp	2022-08-06 03:00:13
authored	[InstanceEdit:9754187] May, Bruce, 2021-09-21
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9754188] May, Bruce, 2021-09-22
edited	[InstanceEdit:9754187] May, Bruce, 2021-09-21
inferredFrom	[Reaction:9754284] Lef1 or Tcf7 (tcf1) and Ctnnb1 bind the Tbxt (T, Brachyury) gene [Mus musculus]
input	[DefinedSet:9754185] LEF1,TCF7 [nucleoplasm] [Homo sapiens] [DefinedSet:9754185] LEF1,TCF7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3451168] CTNNB1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3451168] CTNNB1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9754296] TBPL2 [nucleoplasm] [Homo sapiens] [Complex:9795175] NANOG:TBXT gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9754295] TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes [LiteratureReference:9757060] β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4
modified	[InstanceEdit:9754311] May, Bruce, 2021-09-23 [InstanceEdit:9757068] May, Bruce, 2021-10-24 [InstanceEdit:9761137] May, Bruce, 2022-01-09 [InstanceEdit:9773647] May, Bruce, 2022-05-08 [InstanceEdit:9794696] May, Bruce, 2022-07-19 [InstanceEdit:9794984] May, Bruce, 2022-07-25 [InstanceEdit:9795002] May, Bruce, 2022-07-25 [InstanceEdit:9795178] May, Bruce, 2022-07-30 [InstanceEdit:9796184] May, Bruce, 2022-08-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene
output	[Complex:9754190] LEF1,TCF7:CTNNB1:NANOG:TBPL2:TBXT gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:201669] Beta-catenin translocates to the nucleus [Homo sapiens] [Reaction:201685] Beta-catenin is released from the destruction complex [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9773645] Tam, Patrick P L, 2022-05-08 [InstanceEdit:9794593] Probst, Simone, 2022-07-18 [InstanceEdit:9796183] Zissel, Lea, 2022-07-18 [InstanceEdit:9796182] Salehin, Nazmus, 2022-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9754198] R-HSA-9754191.3
summation	[Summation:9754272] In the mouse embryo Tbxt (T, Brachyury) expression in the pr...
(hasEvent)	[Pathway:9754189] Germ layer formation at gastrulation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:452331] Expression of TBXT (T, Brachyury) in the primitive streak [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9847004] Update Tracker - [Reaction:9754191] LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene - v82:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (9754191)