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Details on Person The ATP-binding cassette sub-family C member transporters (A...
| Class:Id | Summation:9753922 |
|---|---|
| _displayName | The ATP-binding cassette sub-family C member transporters (A... |
| _timestamp | 2021-09-20 12:17:34 |
| created | [InstanceEdit:9753919] Jassal, Bijay, 2021-09-20 |
| text | The ATP-binding cassette sub-family C member transporters (ABCCs, aka multidrug resistance-associated proteins, MRPs) mediate the export of organic anions and drugs from cells. Induction of ABCC expression after APAP-induced liver failure may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. ABCC1, 4 and 5 are thought to efflux the cysteine- and mercapto-conjugates of paracetamol (APAP-Cys and APAP-Mer respectively) from hepatocytes (Barnes et al. 2007). |
| (summation) | [Reaction:9753284] ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region [Homo sapiens] |
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No pathways have been reviewed or authored by The ATP-binding cassette sub-family C member transporters (A... (9753922)
