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Details on Person The effects of paracetamol (APAP) poisoning can be reversed ...
| Class:Id | Summation:9753920 |
|---|---|
| _displayName | The effects of paracetamol (APAP) poisoning can be reversed ... |
| _timestamp | 2021-10-01 13:28:33 |
| created | [InstanceEdit:9753919] Jassal, Bijay, 2021-09-20 |
| literatureReference | [LiteratureReference:9753967] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species |
| modified | [InstanceEdit:9753952] Jassal, Bijay, 2021-09-20 [InstanceEdit:9753966] Jassal, Bijay, 2021-09-20 [InstanceEdit:9753970] Jassal, Bijay, 2021-09-20 [InstanceEdit:9754720] Jassal, Bijay, 2021-10-01 |
| text | The effects of paracetamol (APAP) poisoning can be reversed by administration of N-acetyl-L-cysteine (NAC) within 15hrs of APAP intake. This treatment is effective in preventing liver damage, hepatic failure, renal damage, and death (Prescott et al. 1977, Prescott 1981). NAC provides L-cysteine (L-Cys) for the formation of the tripeptide glutathione, which can conjugate the reactive APAP metabolite N-acetyl-p-benzoquinine imine (NAPQI), thereby reducing damage. NAC is thought to be deacetylated to L-Cys by aminocylase 1 (ACY1), a dimeric enzyme highly expressed in the kidneys (Stocker et al. 2012, review Pedre et al. 2021). |
| (summation) | [Reaction:9753944] ACY1:Zn2+ dimer deacetylates NAC to L-Cys [Homo sapiens] |
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No pathways have been reviewed or authored by The effects of paracetamol (APAP) poisoning can be reversed ... (9753920)
