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Details on Person GGT dimers hydrolyse APAP-SG
Class:Id Reaction:9753634
_displayName GGT dimers hydrolyse APAP-SG
_doRelease TRUE
_timestamp 2021-10-13 09:58:47
authored [InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
catalystActivity [CatalystActivity:8943271] glutathione gamma-glutamate hydrolase activity of GGT dimers [plasma membrane]
catalystActivityReference [CatalystActivityReference:9644481] glutathione hydrolase activity of GGT dimers [plasma membrane] Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase
compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol
created [InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
edited [InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
input [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9753685] APAP-SG [cytosol]
isChimeric FALSE
literatureReference [LiteratureReference:8943268] Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase [LiteratureReference:8943281] Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue [LiteratureReference:1250397] The human gamma-glutamyltransferase gene family [LiteratureReference:1250400] Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney [LiteratureReference:1250401] Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit [LiteratureReference:8943266] Hydrolysis and transfer reactions catalyzed by gamma-glutamyl transpeptidase; evidence for separate substrate sites and for high affinity of L-cystine [LiteratureReference:8943280] Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95 [LiteratureReference:8943264] Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling
modified [InstanceEdit:9753793] Jassal, Bijay, 2021-09-13 [InstanceEdit:9756299] Jassal, Bijay, 2021-10-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name GGT dimers hydrolyse APAP-SG
output [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:9753680] APAP-CysGly [cytosol]
precedingEvent
releaseDate 2021-12-08
reviewed [InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9753700] R-HSA-9753634.2
summation [Summation:9753657] GGT (gamma-glutamyl transpeptidase) dimers associated with t...
(hasEvent) [Pathway:9753281] Paracetamol ADME [Homo sapiens]
(precedingEvent) [Reaction:9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly [Homo sapiens]
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