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Details on Person ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3

Class:Id	Reaction:9753283
_displayName	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3
_doRelease	TRUE
_timestamp	2021-10-13 09:58:15
authored	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
catalystActivity	[CatalystActivity:9753606] ATPase-coupled transmembrane transporter activity of ABCC3, ABCC4 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
edited	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
input	[DefinedSet:9753559] APAP-GlcA, APAP-SO3 [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9753594] Membrane transporters in drug development [LiteratureReference:9753578] Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates
modified	[InstanceEdit:9753451] Jassal, Bijay, 2021-09-07 [InstanceEdit:9753607] Jassal, Bijay, 2021-09-09 [InstanceEdit:9753631] Jassal, Bijay, 2021-09-10 [InstanceEdit:9756299] Jassal, Bijay, 2021-10-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3
output	[DefinedSet:9753562] APAP-GlcA, APAP-SO3 [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:158546] UGTs glucuronate APAP to APAP-GlcA [Homo sapiens] [BlackBoxEvent:9754180] APAP translocates from extracellular region to cytosol [Homo sapiens] [Reaction:9753277] SULT dimers sulfate APAP to APAP-SO3 [Homo sapiens] [BlackBoxEvent:9754180] APAP translocates from extracellular region to cytosol [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9753293] R-HSA-9753283.2
summation	[Summation:9753573] Glucuronidated acetaminophen (APAP-GlcA) and sulfated acetam...
(hasEvent)	[Pathway:9753281] Paracetamol ADME [Homo sapiens]
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No pathways have been reviewed or authored by ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (9753283)