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Details on Person SULT dimers sulfate APAP to APAP-SO3

Class:Id	Reaction:9753277
_displayName	SULT dimers sulfate APAP to APAP-SO3
_doRelease	TRUE
_timestamp	2021-10-13 09:59:19
authored	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
catalystActivity	[CatalystActivity:9753456] sulfotransferase activity of SULT dimers (APAP) [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
edited	[InstanceEdit:9753286] Jassal, Bijay, 2021-09-06
input	[ChemicalDrug:9677362] APAP [cytosol] [SimpleEntity:158471] PAPS [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9753463] Acetaminophen and phenol: substrates for both a thermostable and a thermolabile form of human platelet phenol sulfotransferase [LiteratureReference:9753455] PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses [LiteratureReference:9753453] Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects [LiteratureReference:9753433] Sulphation of acetaminophen by the human cytosolic sulfotransferases: a systematic analysis
modified	[InstanceEdit:9753451] Jassal, Bijay, 2021-09-07 [InstanceEdit:9753607] Jassal, Bijay, 2021-09-09 [InstanceEdit:9754720] Jassal, Bijay, 2021-10-01 [InstanceEdit:9756299] Jassal, Bijay, 2021-10-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SULT dimers sulfate APAP to APAP-SO3
output	[SimpleEntity:158466] PAP [cytosol] [SimpleEntity:9753448] APAP-SO3 [cytosol]
precedingEvent	[BlackBoxEvent:9754180] APAP translocates from extracellular region to cytosol [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9753287] R-HSA-9753277.2
summation	[Summation:9753462] After a therapeutic dose, a large fraction (30-44%) of aceta...
(hasEvent)	[Pathway:9753281] Paracetamol ADME [Homo sapiens]
(precedingEvent)	[Reaction:9753278] ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 [Homo sapiens] [Reaction:9753283] ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 [Homo sapiens]
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No pathways have been reviewed or authored by SULT dimers sulfate APAP to APAP-SO3 (9753277)