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Details on Person First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

Class:Id	Reaction:975180
_displayName	First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
_doRelease	TRUE
_timestamp	2022-03-04 01:54:15
authored	[InstanceEdit:937084] Shamovsky, V, 2010-08-25
catalystActivity	[CatalystActivity:975140] protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
catalystActivityReference	[CatalystActivityReference:9643513] protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] IRAK-4: a novel member of the IRAK family with the properties of an
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:975132] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:165891] IRAK-4: a novel member of the IRAK family with the properties of an [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
modified	[InstanceEdit:1014269] Shamovsky, V, 2010-11-15 [InstanceEdit:1094903] Shamovsky, V, 2010-11-29 [InstanceEdit:1094911] Shamovsky, V, 2010-11-29 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9687809] Shamovsky, Veronica, 2020-05-12 [InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:975130] p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 [Homo sapiens] [Reaction:975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 [Homo sapiens]
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104718] R-HSA-975180.5
summation	[Summation:169775] First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...
(hasEvent)	[Pathway:975155] MyD88 dependent cascade initiated on endosome [Homo sapiens]
(precedingEvent)	[Reaction:975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788205] Update Tracker - [Reaction:975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 - v43:[modifyText]
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No pathways have been reviewed or authored by First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (975180)