Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
Class:Id Complex:975174
_displayName K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
_timestamp 2022-03-04 01:54:35
compartment [Compartment:74700] endosome membrane
created [InstanceEdit:975168] Shamovsky, V, 2010-09-22
hasComponent [Complex:975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:450272] TRAF6 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:450272] TRAF6 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:450272] TRAF6 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:450272] TRAF6 [endosome membrane] [Homo sapiens]
[Complex:975107] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975157] p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975157] p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975157] p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975157] p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] [Homo sapiens]
[Complex:975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975154] K63polyUb-IRF7 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975154] K63polyUb-IRF7 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975154] K63polyUb-IRF7 [endosome membrane] [Homo sapiens]
[EntityWithAccessionedSequence:975154] K63polyUb-IRF7 [endosome membrane] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
modified [InstanceEdit:1565005] Shamovsky, V, 2011-09-06 [InstanceEdit:2428905] Shamovsky, V, 2012-08-08 [InstanceEdit:9689625] Shamovsky, Veronica, 2020-05-21 [InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
name K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9.
relatedSpecies [Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1109000] R-HSA-975174.3
(output) [BlackBoxEvent:975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex [Homo sapiens]
(updatedInstance) [_UpdateTracker:9869997] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v36:[updateContainedComponent] [_UpdateTracker:9870653] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v38:[modifyName, updateContainedComponent] [_UpdateTracker:9871269] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v39:[updateContainedComponent] [_UpdateTracker:9873057] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent] [_UpdateTracker:9877792] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v44:[updateContainedComponent] [_UpdateTracker:9901431] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v73:[updateContainedComponent] [_UpdateTracker:9901606] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v74:[updateContainedComponent] [_UpdateTracker:9902854] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v79:[updateContainedComponent] [_UpdateTracker:9903212] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v80:[updateContainedComponent] [_UpdateTracker:9954021] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v93:[updateContainedComponent]
[Change default viewing format]
List...
Protein identifiers
No pathways have been reviewed or authored by K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (975174)