Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]

Class:IdComplex:975174
_displayNameK63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
_timestamp2022-03-04 01:54:35
compartment[Compartment:74700] endosome membrane
created[InstanceEdit:975168] Shamovsky, V, 2010-09-22
hasComponent
isChimericFALSE
literatureReference[LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
modified[InstanceEdit:1565005] Shamovsky, V, 2011-09-06
[InstanceEdit:2428905] Shamovsky, V, 2012-08-08
[InstanceEdit:9689625] Shamovsky, Veronica, 2020-05-21
[InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
nameK63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9.
relatedSpecies[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1109000] R-HSA-975174.3
(output)[BlackBoxEvent:975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9869997] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v36:[updateContainedComponent]
[_UpdateTracker:9870653] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v38:[modifyName, updateContainedComponent]
[_UpdateTracker:9871269] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v39:[updateContainedComponent]
[_UpdateTracker:9873057] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v42:[addLiteratureReference, updateContainedComponent]
[_UpdateTracker:9877792] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v44:[updateContainedComponent]
[_UpdateTracker:9901431] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v73:[updateContainedComponent]
[_UpdateTracker:9901606] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v74:[updateContainedComponent]
[_UpdateTracker:9902854] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v79:[updateContainedComponent]
[_UpdateTracker:9903212] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v80:[updateContainedComponent]
[_UpdateTracker:9954021] Update Tracker - [Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] - v93:[updateContainedComponent]
[Change default viewing format]
No pathways have been reviewed or authored by K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (975174)