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Details on Person NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9

Class:IdReaction:975119
_displayNameNEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
_doReleaseTRUE
_timestamp2024-07-16 19:49:45
authored[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created[InstanceEdit:975168] Shamovsky, V, 2010-09-22
edited[InstanceEdit:1014278] Shamovsky, V, 2010-11-15
input[Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
[Complex:975172] K63-linked poly-Ub-p-3S,3T-IRAK1:TRAF6 [endosome membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:451426] Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase
[LiteratureReference:451569] Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
[LiteratureReference:450158] Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation
modified[InstanceEdit:1014285] Shamovsky, V, 2010-11-15
[InstanceEdit:1094905] Shamovsky, V, 2010-11-29
[InstanceEdit:1094912] Shamovsky, V, 2010-11-30
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
nameNEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9
output[Complex:975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] [Homo sapiens]
precedingEvent
releaseDate2010-12-14
reviewed[InstanceEdit:983288] Gillespie, ME, 2010-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104655] R-HSA-975119.3
summation[Summation:451573] NF-kappa-B essential modulator (NEMO, also known as IKKG abb...
(hasEvent)[Pathway:975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation [Homo sapiens]
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