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Details on Person IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9

Class:IdReaction:975115
_displayNameIRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
_doReleaseTRUE
_timestamp2024-07-16 19:49:37
authored[InstanceEdit:937084] Shamovsky, V, 2010-08-25
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:975168] Shamovsky, V, 2010-09-22
edited[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
input[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[DefinedSet:937023] IRAK1, IRAK2 [cytosol] [Homo sapiens]
[Complex:975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane] [Homo sapiens]
literatureReference[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory
[LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
[LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control
modified[InstanceEdit:1013003] Shamovsky, V, 2010-11-11
[InstanceEdit:1014273] Shamovsky, V, 2010-11-15
[InstanceEdit:1094904] Shamovsky, V, 2010-11-29
[InstanceEdit:1094911] Shamovsky, V, 2010-11-29
[InstanceEdit:2445243] Shamovsky, V, 2012-08-13
[InstanceEdit:9687809] Shamovsky, Veronica, 2020-05-12
[InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
nameIRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
output[Complex:975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] [Homo sapiens]
precedingEvent
relatedSpecies[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate2010-12-14
reviewed[InstanceEdit:983288] Gillespie, ME, 2010-10-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104253] R-HSA-975115.5
summation[Summation:450116] MYD88 recruits unphosphorylated, inactive IRAK1 to the IL1 r...
[Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
(hasEvent)[Pathway:975155] MyD88 dependent cascade initiated on endosome [Homo sapiens]
(inferredFrom)[Reaction:571324] IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex [Gallus gallus]
(precedingEvent)[Reaction:975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 [Homo sapiens]
[Reaction:975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9782447] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v59:[modifyText]
[_UpdateTracker:9788486] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v42:[addLiteratureReference]
[_UpdateTracker:9789594] Update Tracker - [Reaction:975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. - v37:[modifyText]
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No pathways have been reviewed or authored by IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (975115)
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