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Details on Person MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88

Class:Id	Reaction:975098
_displayName	MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
_doRelease	TRUE
_timestamp	2022-03-04 01:54:47
authored	[InstanceEdit:975060] Shamovsky, V, 2010-09-22
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
edited	[InstanceEdit:1014278] Shamovsky, V, 2010-11-15
input	[EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166059] MYD88 [cytosol] [Homo sapiens] [Complex:975124] MyD88 complexed with the activated TLR receptor [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling [LiteratureReference:936987] An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4 [LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
modified	[InstanceEdit:975222] Shamovsky, V, 2010-09-22 [InstanceEdit:1014284] Shamovsky, V, 2010-11-15 [InstanceEdit:1094905] Shamovsky, V, 2010-11-29 [InstanceEdit:1094912] Shamovsky, V, 2010-11-30 [InstanceEdit:2445244] Shamovsky, V, 2012-08-13 [InstanceEdit:9687809] Shamovsky, Veronica, 2020-05-12 [InstanceEdit:9768151] Shamovsky, Veronica, 2022-03-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
output	[Complex:975114] oligo-MyD88:activated TLR7-9 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 [Homo sapiens] [Reaction:167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands [Homo sapiens] [Reaction:9691204] TLR8 dimer binds TLR7, TLR8 ligands [Homo sapiens] [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 [Homo sapiens] [Reaction:9754830] TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA [Homo sapiens] [Reaction:9724670] C-ter TLR7 dimer binds imiquimod [Homo sapiens] [Reaction:9755765] C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA [Homo sapiens]
relatedSpecies	[Species:9678119] Human SARS coronavirus [Species:164493] Human immunodeficiency virus 1 [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2010-12-14
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105950] R-HSA-975098.4
summation	[Summation:937062] Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 sug...
(hasEvent)	[Pathway:975155] MyD88 dependent cascade initiated on endosome [Homo sapiens]
(normalReaction)	[FailedReaction:5602393] Defective MyD88 does not oligomerize within the activated TLR7/8 complex [Homo sapiens]
(precedingEvent)	[Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788262] Update Tracker - [Reaction:975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - v43:[modifyText] [_UpdateTracker:9788324] Update Tracker - [Reaction:975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - v42:[addLiteratureReference, modifyText] [_UpdateTracker:9789719] Update Tracker - [Reaction:975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - v37:[modifyText]
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