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Details on Person Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

Class:Id	Reaction:975097
_displayName	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
_doRelease	TRUE
_timestamp	2021-08-18 17:10:18
authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
input	[Complex:975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Complex:446878] TAK1 complex [cytosol] [Homo sapiens] [Complex:446878] TAK1 complex [cytosol] [Homo sapiens] [Complex:446878] TAK1 complex [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains [LiteratureReference:208287] TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
modified	[InstanceEdit:1014265] Shamovsky, V, 2010-11-15 [InstanceEdit:1094901] Shamovsky, V, 2010-11-29 [InstanceEdit:1094911] Shamovsky, V, 2010-11-29 [InstanceEdit:9710952] Shamovsky, Veronica, 2021-01-06 [InstanceEdit:9716659] Shamovsky, Veronica, 2021-02-23 [InstanceEdit:9736377] Shamovsky, Veronica, 2021-07-07 [InstanceEdit:9751162] Shamovsky, Veronica, 2021-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
output	[Complex:975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] [Homo sapiens]
precedingEvent	[Polymerisation:450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Homo sapiens] [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane [Homo sapiens] [BlackBoxEvent:936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex [Homo sapiens] [BlackBoxEvent:975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane [Homo sapiens] [Reaction:975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105630] R-HSA-975097.4
summation	[Summation:447018] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
(hasEvent)	[Pathway:975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation [Homo sapiens]
(inferredFrom)	[Reaction:573296] Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation [Gallus gallus]
(precedingEvent)	[Reaction:975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776371] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v76:[modifyText] [_UpdateTracker:9788163] Update Tracker - [Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - v43:[modifyText]
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