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Details on Person ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells

Class:Id	Reaction:9750656
_displayName	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells
_doRelease	TRUE
_timestamp	2021-11-12 15:05:42
authored	[InstanceEdit:9749991] Stephan, Ralf, 2021-08-09
catalystActivity	[CatalystActivity:9750667] ABC-type transporter activity of ABCC2, ABCC3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[DefinedSet:9750692] salicylate metabolites [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[URL:9750689] https://helda.helsinki.fi/bitstream/handle/10138/307418/Humaneff.pdf?isAllowed=y&sequence=1 [LiteratureReference:9750686] Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells [LiteratureReference:9750669] Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3) [Book:9750696] 9789401164702 Lote, Christopher Principles of Renal Physiology
modified	[InstanceEdit:9750966] Stephan, Ralf, 2021-08-17 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757460] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells ABCC2, ABCC3 transport salicylate metabolites out of hepatic cells
output	[DefinedSet:9750678] salicylate metabolites [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:9750660] Glycine conjugates translocates from mitochondrial matrix to cytosol [Homo sapiens] [Reaction:9750001] GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid [Homo sapiens] [Reaction:159574] GLYAT-like proteins transfer glycine to ST-CoA to form SUA [Homo sapiens] [BlackBoxEvent:9757459] ST metabolites diffuse out of ER lumen [Homo sapiens] [Reaction:9757462] Hydroxyl radicals oxidize ST to 2,3-DHBA [Homo sapiens] [Reaction:9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA [Homo sapiens] [Reaction:9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA [Homo sapiens] [Reaction:9749977] UGT1A6 glucuronates ST [Homo sapiens] [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9750720] R-HSA-9750656.2
summation	[Summation:9750673] ATP-binding cassette sub-family C members 2 and 3 (ABCC2, AB...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
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No pathways have been reviewed or authored by ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (9750656)