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Details on Person ABCC5 transports TPMP substrates from cytosol to extracellular region

Class:Id	Reaction:9750617
_displayName	ABCC5 transports TPMP substrates from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2021-10-19 12:35:07
authored	[InstanceEdit:9750573] Jassal, Bijay, 2021-08-16
catalystActivity	[CatalystActivity:9750627] ATPase-coupled transmembrane transporter activity of ABCC5 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9750573] Jassal, Bijay, 2021-08-16
edited	[InstanceEdit:9750573] Jassal, Bijay, 2021-08-16
goBiologicalProcess	[GO_BiologicalProcess:22548] xenobiotic transmembrane transport
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol] [DefinedSet:9750557] ABCC5 TPMP substrates [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9750581] Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells [LiteratureReference:9750632] Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs [LiteratureReference:9750626] Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5)
modified	[InstanceEdit:9750967] Jassal, Bijay, 2021-08-17 [InstanceEdit:9755271] Jassal, Bijay, 2021-10-07 [InstanceEdit:9756882] Jassal, Bijay, 2021-10-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ABCC5 transports TPMP substrates from cytosol to extracellular region ABCC5 transports thiopurine monophosphates from cytosol to extracellular region
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [DefinedSet:9750602] ABCC5 TPMP substrates [extracellular region]
precedingEvent	[Reaction:9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP [Homo sapiens] [Reaction:9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP [Homo sapiens] [Reaction:9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP [Homo sapiens] [Reaction:9748996] GST dimers cleave AZA to 6MP [Homo sapiens] [Reaction:9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP [Homo sapiens] [Reaction:9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP [Homo sapiens] [Reaction:9748957] GMPS dimer transforms 6TXMP to 6TGMP [Homo sapiens] [Reaction:9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9750641] R-HSA-9750617.2
summation	[Summation:9750968] ABCC5 is a multidrug resistance protein (MRP5) which can tra...
(hasEvent)	[Pathway:9748787] Azathioprine ADME [Homo sapiens]
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