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Details on Person UniProt:Q21241 lect-2
| Class:Id | ReferenceGeneProduct:9750307 |
|---|---|
| _chainChangeLog | signal peptide:1-20 for 9750307 added on Wed August 11 2021;chain:21-335 for 9750307 added on Wed August 11 2021 |
| _displayName | UniProt:Q21241 lect-2 |
| _timestamp | 2023-11-03 15:08:57 |
| chain | signal peptide:1-20 chain:21-335 |
| checksum | A22B9BF7A59ADAB2 |
| comment | FUNCTION Muscle-derived dendritic guidance cue, which is required for the formation of somatosensory dendritic arbors which extend from PVD and FLP sensory neurons during development (PubMed:27451901). Ligand of a multi-protein dma-1 receptor-ligand complex, which is activated upon binding of lect-2, mnr-1 and sax-7 ligands to control the growth of dendrites that extend anteriorly from the PVD neuronal cell body (PubMed:27451901, PubMed:27705746). Enhances the binding of the mnr-1 and sax-7 ligands to the dma-1 receptor-ligand complex (PubMed:27705746). Restricts the growth of secondary PVD dendritic branches and any irregularly positioned ectopic tertiary dendritic branches that originate from secondary branches, and promotes the formation of stable higher order dendritic branches (PubMed:27451901, PubMed:27705746). In particular, it is required for the formation of quaternary PVD dendritic branches and promotes their innervation of body wall muscles (PubMed:27705746). Promotes self-avoidance of tertiary dendritic branches of PVD sensory neurons (PubMed:27451901). Not required for the growth of dendrites that extend from AIY and PVQ interneurons, DVB GABergic neurons, PLM and ALM mechanosensory neurons, AFD sensory neurons and DD/VD and DA/DB motor neurons (PubMed:27451901).SUBUNIT Component of a multi-protein dma-1 receptor-ligand complex, which is activated upon binding of lect-2, mnr-1 and sax-7 ligands to promote the morphogenesis of dendrites which extend from the PVD neuronal body (PubMed:27705746). Within the complex interacts with sax-7; the interaction is required for lect-2 dendritic localization and enhances the binding of the mnr-1 and sax-7 ligands to the dma-1 receptor-ligand complex (PubMed:27705746).SUBCELLULAR LOCATION Secreted by body wall muscles and taken up by coelomocytes (PubMed:27451901, PubMed:27705746). Localizes to the basement membrane of hypodermal tissues, body wall muscles and along fibrous organelles in larvae and adults (PubMed:27451901). Co-localizes with sax-7 at dendrites (PubMed:27451901, PubMed:27705746). Dendritic localization is dependent on sax-7, but not mnr-1 or dma-1 (PubMed:27451901, PubMed:27705746).TISSUE SPECIFICITY Expressed in body wall muscle cells, along the boundary of the lateral hypodermis, seam cells, processes of the nervous system including commissures, sensory dendrites in the head, and lateral nerve tracts, and motor neurons and some mechanosensory neurons such as ALM.DEVELOPMENTAL STAGE Expressed throughout development (PubMed:27451901). Diffusely expressed from the gastrula stage to the 3-fold embryonic stage (PubMed:27451901). In larvae, expressed in hypodermal tissues and processes of the nervous system, including commissures, sensory dendrites in the head, and lateral nerve tracts (PubMed:27451901). In L3 and L4 stage larvae, mainly expressed in body wall muscles, and it is also expressed in head neurons and ventral nerve cord neurons (PubMed:27705746).SIMILARITY Belongs to the LECT2/MIM-1 family. |
| created | [InstanceEdit:9750299] Weiser, JD |
| description | recommendedName: fullName evidence="10"Leukocyte cell-derived chemotaxin-2 homolog alternativeName: fullName evidence="7"Chondromodulin II |
| geneName | lect-2 K05F1.5 |
| identifier | Q21241 |
| isSequenceChanged | FALSE |
| keyword | Basement membrane Cell junction Cell projection Disulfide bond Extracellular matrix Glycoprotein Metal-binding Neurogenesis Reference proteome Secreted Signal Zinc |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | lect-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | LECT2_CAEEL A0A1B1LVF5 |
| sequenceLength | 335 |
| species | [Species:68320] Caenorhabditis elegans |
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No pathways have been reviewed or authored by UniProt:Q21241 lect-2 (9750307)
