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Details on Person UniProt:Q6DGG9 Camlg
| Class:Id | ReferenceGeneProduct:9750306 |
|---|---|
| _chainChangeLog | chain:1-295 for 9750306 added on Wed August 11 2021 |
| _displayName | UniProt:Q6DGG9 Camlg |
| _timestamp | 2023-11-03 17:47:34 |
| chain | chain:1-295 |
| checksum | FA840DD127E3B1EF |
| comment | FUNCTION Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287). Required for the stability of GET1 (By similarity). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity). Essential for the survival of peripheral follicular B cells (By similarity).SUBUNIT Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40 (PubMed:23041287). Within the complex, GET1 and CAMLG form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer (By similarity). Interacts (via C-terminus) with GET1 (PubMed:23041287). Interacts (via N-terminus) with GET3 (PubMed:23041287). GET3 shows a higher affinity for CAMLG than for GET1 (By similarity). Interacts (via N-terminus) with TNFRSF13B/TACI (via C-terminus) (By similarity).SUBCELLULAR LOCATION In the central nervous system, expressed in astrocytes, microglia and neurons (at protein level). |
| created | [InstanceEdit:9750299] Weiser, JD |
| description | recommendedName: fullName evidence="8"Guided entry of tail-anchored proteins factor CAMLG alternativeName: fullName evidence="1"Calcium signal-modulating cyclophilin ligand |
| geneName | Camlg Caml Get2 |
| identifier | Q6DGG9 |
| isSequenceChanged | FALSE |
| keyword | Disulfide bond Endoplasmic reticulum ER-Golgi transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Camlg |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CAMLG_RAT F7FMD6 Q9ERK1 |
| sequenceLength | 295 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6DGG9 Camlg (9750306)
