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Details on Person UniProt:Q86MD3-1 atf-7
| Class:Id | ReferenceIsoform:9750301 |
|---|---|
| _chainChangeLog | chain:1-509 for 9750301 added on Wed August 11 2021 |
| _displayName | UniProt:Q86MD3-1 atf-7 |
| _timestamp | 2023-11-03 16:00:03 |
| chain | chain:1-509 |
| checksum | 7CD869FAB173950D |
| comment | FUNCTION Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses (PubMed:20369020, PubMed:28632756, PubMed:30789901). Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901). Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381). Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901). May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853). May be phosphorylated by pmk-1 (PubMed:20369020). Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).SUBUNIT Interacts with serine/threonine kinase pmk-1; perhaps in a manner dependent on dual specificity protein kinase sek-1.SUBCELLULAR LOCATION Expressed in intestinal cells.DISRUPTION PHENOTYPE RNAi-mediated knockdown increases susceptibility to infection by the Gram-negative bacterium P.aeruginosa (PubMed:20369020). Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).SIMILARITY Belongs to the bZIP family. |
| created | [InstanceEdit:9750299] Weiser, JD |
| description | recommendedName: fullName evidence="8"Transcription factor atf-7 alternativeName: fullName evidence="12"cAMP-dependent transcription factor family member 7 |
| geneName | atf-7 C07G2.2 |
| identifier | Q86MD3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromosome Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | atf-7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ATF7_CAEEL B3GWA6 Q17801 Q9U3R1 |
| sequenceLength | 509 |
| species | [Species:68320] Caenorhabditis elegans |
| variantIdentifier | Q86MD3-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q86MD3-1 atf-7 (9750301)
