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Details on Person GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid

Class:IdReaction:9750001
_displayNameGLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
_doReleaseTRUE
_timestamp2021-11-12 15:07:24
authored[InstanceEdit:9749991] Stephan, Ralf, 2021-08-09
catalystActivity[CatalystActivity:159547] glycine N-benzoyltransferase activity of GLYAT-like proteins [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:9749991] Stephan, Ralf, 2021-08-09
edited[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input[SimpleEntity:159549] Gly [mitochondrial matrix]
[SimpleEntity:9749985] 2,5-DHB-CoA [mitochondrial matrix]
literatureReference[LiteratureReference:159562] Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man
[LiteratureReference:177161] Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver
[LiteratureReference:9750004] The metabolism of aspirin in man: a population study
modified[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16
[InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22
[InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22
[InstanceEdit:9758463] Stephan, Ralf, 2021-11-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
2,5-DHBA-CoA + glycine => gentisuric acid + Coenzyme A
2,5-DHBA-CoA forms an amide bond with glycine
output[SimpleEntity:29374] CoA-SH [mitochondrial matrix]
[SimpleEntity:9750005] gentisuric acid [mitochondrial matrix]
precedingEvent
releaseDate2021-12-08
reviewed[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9750017] R-HSA-9750001.2
summation[Summation:9750704] GLYAT-like enzymes catalyze the transfer of acyl groups from...
(hasEvent)[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9761240] Abundant Molecules: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
[BlackBoxEvent:9750660] Glycine conjugates translocates from mitochondrial matrix to cytosol [Homo sapiens]
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