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Details on Person CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA

Class:Id	Reaction:9749986
_displayName	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA
_doRelease	TRUE
_timestamp	2022-01-11 09:41:12
authored	[InstanceEdit:9749791] Stephan, Ralf, 2021-08-05
catalystActivity	[CatalystActivity:9749975] monooxygenase activity of CYP2,3 cytochromes [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9749991] Stephan, Ralf, 2021-08-09
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:9749790] ST (hepatocyte) [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749983] 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism [LiteratureReference:9749979] Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450
modified	[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757450] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9761241] Stephan, Ralf, 2022-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA
output	[SimpleEntity:9750011] 2,3-DHBA [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9750018] R-HSA-9749986.3
summation	[Summation:9750007] 2,3-Dihydroxybenzoate (2,3-DHBA) is a minor oxidation produc...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9750713] ST metabolites diffuse out of ER lumen [BlackBoxEvent:9757459] ST metabolites diffuse out of ER lumen [Homo sapiens]
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No pathways have been reviewed or authored by CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (9749986)