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Details on Person ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA

Class:Id	Reaction:9749971
_displayName	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA
_doRelease	TRUE
_timestamp	2022-01-11 09:40:57
authored	[InstanceEdit:9750966] Stephan, Ralf, 2021-08-17
catalystActivity	[CatalystActivity:159441] CoA-ligase activity of ACSM2B-like proteins [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9749991] Stephan, Ralf, 2021-08-09
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:113593] ATP [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:9750012] 2,5-DHBA [mitochondrial matrix]
literatureReference	[LiteratureReference:159555] Pharmacokinetics of salicylate elimination in man [LiteratureReference:159552] Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria [LiteratureReference:9750004] The metabolism of aspirin in man: a population study [LiteratureReference:159570] Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids
modified	[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9753825] Stephan, Ralf, 2021-09-14 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757457] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9761241] Stephan, Ralf, 2022-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA 2,5-DHBA + Coenzyme A + ATP => 2,5-DHBA-CoA + AMP + pyrophosphate 2,5-DHBA and Coenzyme A react to form 2,5-DHBA-CoA thioester
negativePrecedingEvent	[NegativePrecedingEvent:9761240] Abundant Molecules: GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid
output	[SimpleEntity:159448] AMP [mitochondrial matrix] [SimpleEntity:159450] PPi [mitochondrial matrix] [SimpleEntity:9749985] 2,5-DHB-CoA [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:9757456] 2,5-DHBA translocates from ER lumen to mitochondrial matrix [Homo sapiens] [Reaction:9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9750024] R-HSA-9749971.3
summation	[Summation:9750703] ACSM2B-like enzymes catalyze the transfer of acyl groups ont...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9750001] GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid [Homo sapiens]
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