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Details on Person CES1,CES2 hydrolyze ASA- to ST

Class:Id	Reaction:9749792
_displayName	CES1,CES2 hydrolyze ASA- to ST
_doRelease	TRUE
_timestamp	2021-11-12 15:06:55
authored	[InstanceEdit:9750966] Stephan, Ralf, 2021-08-17
catalystActivity	[CatalystActivity:5693697] carboxylic ester hydrolase activity of CES1 trimer, CES2 [endoplasmic reticulum lumen]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9749791] Stephan, Ralf, 2021-08-05
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:9749795] ASA- (hepatocyte) [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749538] Absorption kinetics of aspirin in man following oral administration of an aqueous solution [LiteratureReference:9749663] Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid [LiteratureReference:9749670] Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine [LiteratureReference:9749619] Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol [LiteratureReference:9749608] Human carboxylesterase isozymes: catalytic properties and rational drug design [LiteratureReference:9749617] Carboxylesterases in lipid metabolism: from mouse to human [LiteratureReference:9749560] Comparative study of human intestinal and hepatic esterases as related to enzymatic properties and hydrolizing activity for ester-type drugs [LiteratureReference:9756900] Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver
modified	[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9753825] Stephan, Ralf, 2021-09-14 [InstanceEdit:9756903] Shamovsky, Veronica, 2021-10-20 [InstanceEdit:9756909] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757450] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CES1,CES2 hydrolyze ASA- to ST
output	[SimpleEntity:156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:9749588] acetate [endoplasmic reticulum lumen] [SimpleEntity:9749790] ST (hepatocyte) [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749804] R-HSA-9749792.2
summation	[Summation:9749562] CES1 and CES2 hydrolyze acetylsalicylate (ASA-) in hepatic c...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates [Homo sapiens] [Reaction:9749977] UGT1A6 glucuronates ST [Homo sapiens] [Reaction:9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA [Homo sapiens] [Reaction:9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA [Homo sapiens] [Reaction:9757462] Hydroxyl radicals oxidize ST to 2,3-DHBA [Homo sapiens]
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No pathways have been reviewed or authored by CES1,CES2 hydrolyze ASA- to ST (9749792)