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Details on Person CES2 hydrolyzes ASA-

Class:Id	Reaction:9749647
_displayName	CES2 hydrolyzes ASA-
_doRelease	TRUE
_timestamp	2021-11-12 15:07:03
authored	[InstanceEdit:9749644] Stephan, Ralf, 2021-08-03
catalystActivity	[CatalystActivity:9749798] carboxylesterase activity of CES2 [endoplasmic reticulum lumen]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:9749589] Stephan, Ralf, 2021-08-04
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:9749582] ASA- (GI cell) [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749538] Absorption kinetics of aspirin in man following oral administration of an aqueous solution [LiteratureReference:9749663] Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid [LiteratureReference:9749670] Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine [LiteratureReference:9749619] Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol [LiteratureReference:9749608] Human carboxylesterase isozymes: catalytic properties and rational drug design [LiteratureReference:9749617] Carboxylesterases in lipid metabolism: from mouse to human [LiteratureReference:9749560] Comparative study of human intestinal and hepatic esterases as related to enzymatic properties and hydrolizing activity for ester-type drugs
modified	[InstanceEdit:9749791] Stephan, Ralf, 2021-08-05 [InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9756909] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757439] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CES2 hydrolyzes ASA-
output	[SimpleEntity:9749593] ST (GI cell) [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:9749588] acetate [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:9757438] ASA- translocates from cytosol to ER lumen of GI cells [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749679] R-HSA-9749647.2
summation	[Summation:9749787] CES2 hydrolyzes acetylsalicylate (ASA-) in GI cells. Althoug...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9757445] ST translocates from ER lumen to cytosol of GI cells [Homo sapiens]
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