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Details on Person BCHE hydrolyzes ASA-

Class:Id	Reaction:9749609
_displayName	BCHE hydrolyzes ASA-
_doRelease	TRUE
_timestamp	2021-11-12 15:06:47
authored	[InstanceEdit:9749644] Stephan, Ralf, 2021-08-03
catalystActivity	[CatalystActivity:9749547] hydrolase activity, acting on ester bonds of BCHE [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9749589] Stephan, Ralf, 2021-08-04
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[SimpleEntity:9749598] ASA- [extracellular region] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749616] Plasma aspirin esterases in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterization and the importance of the enzymic components [LiteratureReference:9749606] Identification and partial purification of the major aspirin hydrolyzing enzyme in human blood
modified	[InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9753825] Stephan, Ralf, 2021-09-14 [InstanceEdit:9756909] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757442] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BCHE hydrolyzes ASA-
output	[SimpleEntity:9749546] ST [extracellular region] [SimpleEntity:1524044] acetate [extracellular region] [SimpleEntity:351626] H+ [extracellular region]
precedingEvent	[BlackBoxEvent:9757441] ASA- (GI) translocates from cytosol to extracellular region [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [BlackBoxEvent:9757445] ST translocates from ER lumen to cytosol of GI cells [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749682] R-HSA-9749609.2
summation	[Summation:9749672] Acetylsalicylate (ASA-) is hydrolyzed by two plasma esterase...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens] [Reaction:9750666] ALB binds ST [Homo sapiens]
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