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Details on Person SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes

Class:Id	Reaction:9749583
_displayName	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes
_doRelease	TRUE
_timestamp	2022-01-11 09:41:42
authored	[InstanceEdit:9749644] Stephan, Ralf, 2021-08-03
catalystActivity	[CatalystActivity:9749553] secondary active transmembrane transporter activity of SLC22A7 [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:9749589] Stephan, Ralf, 2021-08-04
edited	[InstanceEdit:9758462] Stephan, Ralf, 2021-11-12
input	[DefinedSet:9749786] ASA-, ST [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749613] Difference in hepatic uptake kinetics of aspirin and salicylamide in rats [LiteratureReference:9749658] Identification of multispecific organic anion transporter 2 expressed predominantly in the liver [LiteratureReference:561060] Isolation of a family of organic anion transporters from human liver and kidney
modified	[InstanceEdit:9749791] Stephan, Ralf, 2021-08-05 [InstanceEdit:9750653] Stephan, Ralf, 2021-08-16 [InstanceEdit:9756909] Shamovsky, Veronica, 2021-10-21 [InstanceEdit:9756980] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9756981] Shamovsky, Veronica, 2021-10-22 [InstanceEdit:9757442] Stephan, Ralf, 2021-11-01 [InstanceEdit:9757447] Stephan, Ralf, 2021-11-01 [InstanceEdit:9758463] Stephan, Ralf, 2021-11-12 [InstanceEdit:9761241] Stephan, Ralf, 2022-01-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes SLC22A7 transports ASA-,ST into liver cells
output	[DefinedSet:9749576] ASA-, ST (hepatocyte) [cytosol]
precedingEvent	[BlackBoxEvent:9757441] ASA- (GI) translocates from cytosol to extracellular region [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells [Homo sapiens] [BlackBoxEvent:9757445] ST translocates from ER lumen to cytosol of GI cells [Homo sapiens] [BlackBoxEvent:9757448] ST translocates from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:9757445] ST translocates from ER lumen to cytosol of GI cells [Homo sapiens] [Reaction:9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol [Homo sapiens] [Reaction:9749609] BCHE hydrolyzes ASA- [Homo sapiens] [BlackBoxEvent:9757441] ASA- (GI) translocates from cytosol to extracellular region [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749685] R-HSA-9749583.3
summation	[Summation:9749600] SLC22A7 is a sodium-independent multispecific organic anion ...
(hasEvent)	[Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[Reaction:2314678] ASA- acetylates PTGS1 [Homo sapiens] [Reaction:2314686] ASA- acetylates PTGS2 [Homo sapiens] [BlackBoxEvent:9749793] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [BlackBoxEvent:9757454] ST translocates from cytosol to mitochondrial matrix of hepatocytes [Homo sapiens]
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