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Details on Person Inhibitor of nuclear factor kappa-B kinase-interacting prote...
| Class:Id | Summation:9749489 |
|---|---|
| _displayName | Inhibitor of nuclear factor kappa-B kinase-interacting prote... |
| _timestamp | 2021-08-04 03:39:38 |
| created | [InstanceEdit:9749474] Shamovsky, Veronica, 2021-08-04 |
| literatureReference | [LiteratureReference:9749498] A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53 [LiteratureReference:6791355] APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis [LiteratureReference:9749457] APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death |
| text | Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP, also known as IKIP) is located on the chromosome 12, within 0.5 kbp upstream of the apoptotic protease-activating factor 1 (APAF1) (Hofer-Warbinek R et al. 2004). IKBIP and APAF1 share a common promoter which coordinates expression of two genes in opposite directions. Expression of APAF1 was shown to be regulated by transcription factor TP53 (p53) which binds to the p53 response element in the promoter of the APAF1 gene (Robles AI et al. 2001; Fortin A et al. 2001). Like APAF1, expression of IKBIP is also regulated by TP53 (Hofer-Warbinek R et al. 2004). This Reactome event shows binding of TP53 to the p53 response element in the promoter region of the IKBIP/APAF1 genes. |
| (summation) | [Reaction:9749464] TP53 binds the IKBIP gene promoter [Homo sapiens] |
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No pathways have been reviewed or authored by Inhibitor of nuclear factor kappa-B kinase-interacting prote... (9749489)
