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Details on Person TP53 stimulates IKBIP gene expression

Class:Id	BlackBoxEvent:9749487
_displayName	TP53 stimulates IKBIP gene expression
_doRelease	TRUE
_timestamp	2022-05-18 13:22:06
authored	[InstanceEdit:9758466] Shamovsky, Veronica, 2021-11-12
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9749474] Shamovsky, Veronica, 2021-08-04
edited	[InstanceEdit:9773904] Shamovsky, Veronica, 2022-05-10
input	[EntityWithAccessionedSequence:9749483] IKBIP gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749498] A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53
modified	[InstanceEdit:9762356] Shamovsky, Veronica, 2022-01-20 [InstanceEdit:9773241] Shamovsky, Veronica, 2022-05-04 [InstanceEdit:9773817] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9774033] Shamovsky, Veronica, 2022-05-12 [InstanceEdit:9774121] Shamovsky, Veronica, 2022-05-17 [InstanceEdit:9774130] Matthews, Lisa, 2022-05-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates IKBIP gene expression
output	[EntityWithAccessionedSequence:9749482] IKBIP [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9749464] TP53 binds the IKBIP gene promoter [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9749493] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:IKBIP Gene [nucleoplasm]'
regulationReference	[RegulationReference:9749452] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:IKBIP Gene [nucleoplasm]' A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53
releaseDate	2022-06-09
reviewed	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05 [InstanceEdit:9773242] de Martin, R, 2022-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749518] R-HSA-9749487.2
summation	[Summation:9749466] Inhibitor of nuclear factor kappa-B kinase-interacting prote...
(hasEvent)	[Pathway:9758274] Regulation of NF-kappa B signaling [Homo sapiens]
(precedingEvent)	[Reaction:9749494] IKBIP binds IKBKB and CHUK [Homo sapiens]
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No pathways have been reviewed or authored by TP53 stimulates IKBIP gene expression (9749487)