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Details on Person CDT1-mediated formation of MCM2-7 double hexamer at the replication origin

Class:Id	Reaction:9749351
_displayName	CDT1-mediated formation of MCM2-7 double hexamer at the replication origin
_doRelease	TRUE
_timestamp	2021-11-03 16:55:09
authored	[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9749352] Orlic-Milacic, Marija, 2021-08-01
edited	[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
inferredFrom	[Reaction:9749401] CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast [Saccharomyces cerevisiae]
input	[Complex:9749356] ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] [Homo sapiens] [Complex:9749283] CDT1:MCM2-7 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9749362] Orlic-Milacic, Marija, 2021-08-01 [InstanceEdit:9749396] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9749399] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9749400] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9749405] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9749411] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9757626] Orlic-Milacic, Marija, 2021-11-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDT1-mediated formation of MCM2-7 double hexamer at the replication origin
output	[Complex:9749359] ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68536] CDT1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9749350] ATP-dependent release of CDT1 from the OCCM complex [Homo sapiens] [Reaction:9749320] CDT1-mediated loading of MCM2-7 to replication origins [Homo sapiens]
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749354] R-HSA-9749351.2
summation	[Summation:9749398] Based on studies in budding yeast, after CDT1-mediated loadi...
(hasEvent)	[Pathway:68867] Assembly of the pre-replicative complex [Homo sapiens] [Pathway:9734667] (NEW) Assembly of the ORC complex at the origin of replication [Homo sapiens]
(replacementInstances)	[_Deleted:9768313] Deletion of instance: 68827
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No pathways have been reviewed or authored by CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (9749351)